acetic acid-(2,5-dimethoxy-4-methyl-anilide)

Base Information

• Chemical Name: acetic acid-(2,5-dimethoxy-4-methyl-anilide)
• CAS No.: 53939-66-5
• Molecular Formula: C₁₁H₁₅NO₃
• Molecular Weight: 209.245
• Mol file: 53939-66-5.mol

Synonyms:

Chemical Property of acetic acid-(2,5-dimethoxy-4-methyl-anilide)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of acetic acid-(2,5-dimethoxy-4-methyl-anilide)

There total 13 articles about acetic acid-(2,5-dimethoxy-4-methyl-anilide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-iodo-2,5-dimethoxy-4-methylbenzene (75056-76-7) → acetic acid-(2,5-dimethoxy-4-methyl-anilide) (53939-66-5)

Guidance literature:

Multi-step reaction with 4 steps

1: butyl lithium; diethyl ether / anschliessend Behandeln mit Kohlendioxid

2: glacial acetic acid; concentrated nitric acid / 45 °C

3: Raney nickel; ethanol / 100 °C / Hydrogenation

With n-butyllithium; diethyl ether; ethanol; nitric acid; nickel; acetic acid;

DOI:10.1021/ja01233a042

Reference yield:

4-methyl-2,5-dimethoxy-benzoic acid (32176-94-6) → acetic acid-(2,5-dimethoxy-4-methyl-anilide) (53939-66-5)

Guidance literature:

Multi-step reaction with 3 steps

1: glacial acetic acid; concentrated nitric acid / 45 °C

2: Raney nickel; ethanol / 100 °C / Hydrogenation

With ethanol; nitric acid; nickel; acetic acid;

DOI:10.1021/ja01233a042

Reference yield:

1,4-dimethoxy-2-methyl-5-nitrobenzene (32185-64-1) → acetic acid-(2,5-dimethoxy-4-methyl-anilide) (53939-66-5)

Guidance literature:

Multi-step reaction with 2 steps

1: Raney nickel; ethanol / 100 °C / Hydrogenation

With ethanol; nickel;

DOI:10.1021/ja01233a042

upstream raw materials:

2,5-dimethoxy-4-methylaniline

acetic anhydride

acetic acid-(2,5-dihydroxy-4-methyl-anilide)

methyl iodide

Downstream raw materials:

2,5-dimethoxy-4-methylaniline