1-phenyl-3-methyl-4,5,6,7-tetrahydroindene

Base Information

• Chemical Name: 1-phenyl-3-methyl-4,5,6,7-tetrahydroindene
• CAS No.: 857505-15-8
• Molecular Formula: C₁₆H₁₈
• Molecular Weight: 210.319
• Mol file: 857505-15-8.mol

Synonyms:

Chemical Property of 1-phenyl-3-methyl-4,5,6,7-tetrahydroindene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-phenyl-3-methyl-4,5,6,7-tetrahydroindene

There total 2 articles about 1-phenyl-3-methyl-4,5,6,7-tetrahydroindene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

3-methyl-2,3,4,5,6,7-hexahydro-inden-1-one (18631-68-0) + phenylmagnesium bromide → 1-phenyl-3-methyl-4,5,6,7-tetrahydroindene (857505-15-8)

Guidance literature:

In diethyl ether; at 20 ℃; for 15h;

DOI:10.1016/S0022-328X(99)00446-5

Reference yield:

cyclohexene (110-83-8) → 1-phenyl-3-methyl-4,5,6,7-tetrahydroindene (857505-15-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 55 percent / polyphosphoric acid / 2 h / 60 °C

2: 52 percent / diethyl ether / 15 h / 20 °C

With PPA; In diethyl ether; 1: Cyclization / 2: Grignard reaction;

DOI:10.1016/S0022-328X(99)00446-5

Reference yield: 22.0%

dodecacarbonyl-triangulo-triruthenium (15243-33-1) + 1-phenyl-3-methyl-4,5,6,7-tetrahydroindene (857505-15-8) → bis(3-methyl-1-phenyl-4,5,6,7-tetrahydroindenyl)diruthenium tetracarbonyl (676362-70-2)

Guidance literature:

In n-heptane; refluxed in n-heptane (20 h); cooled to room temp.; chromd. (Al2O3); crystd. from CH2Cl2/n-heptane (1:1);

DOI:10.1023/A:1024735214909

upstream raw materials:

3-methyl-2,3,4,5,6,7-hexahydro-inden-1-one

cyclohexene

Downstream raw materials:

bis(3-methyl-1-phenyl-4,5,6,7-tetrahydroindenyl)diruthenium tetracarbonyl

Refernces