1-[4-(Benzoyloxy)-2-hydroxyphenyl]-3-phenyl-1,3-propanedione

Base Information

• Chemical Name: 1-[4-(Benzoyloxy)-2-hydroxyphenyl]-3-phenyl-1,3-propanedione
• CAS No.: 5465-06-5
• Molecular Formula: C22H16 O5
• Molecular Weight: 360.366
• Hs Code.: 2916310090
• Mol file: 5465-06-5.mol

Synonyms:1,3-Propanedione,1-(2,4-dihydroxyphenyl)-3-phenyl-, 4-benzoate (6CI,7CI); NSC 26749

Chemical Property of 1-[4-(Benzoyloxy)-2-hydroxyphenyl]-3-phenyl-1,3-propanedione

Chemical Property:

• Vapor Pressure: 5.34E-14mmHg at 25°C
• Melting Point: 167 °C
• Boiling Point: 578.8°Cat760mmHg
• PKA: 6.82±0.35(Predicted)
• Flash Point: 206.5°C
• PSA: 80.67000
• Density: 1.292g/cm³
• LogP: 4.06710

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-[4-(Benzoyloxy)-2-hydroxyphenyl]-3-phenyl-1,3-propanedione

There total 13 articles about 1-[4-(Benzoyloxy)-2-hydroxyphenyl]-3-phenyl-1,3-propanedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2',4'-dihydroxy-4-acetophenone (89-84-9) + benzoyl chloride (98-88-4) → <4-(benzoyloxy)-2-hydroxybenzoyl>benzoylmethane (5465-06-5)

Guidance literature:

With tetrabutylammomium bromide; potassium carbonate; In acetone; for 14.5h; Reflux; Phase transfer conditions;

DOI:10.3184/030823409X431346

Reference yield: 77.1%

2,4-dibenzoyloxyacetophenone (66832-97-1) → <4-(benzoyloxy)-2-hydroxybenzoyl>benzoylmethane (5465-06-5)

Guidance literature:

With pyridine; potassium hydroxide; at 50 ℃; for 0.5h;

DOI:10.1007/s11172-013-0289-5

Reference yield: 75.0%

2,4-dibenzoyloxyacetophenone (66832-97-1) → <4-(benzoyloxy)-2-hydroxybenzoyl>benzoylmethane (5465-06-5) + 7-hydroxy-2-phenyl-3-benzoylchromone (117096-61-4)

Guidance literature:

With potassium carbonate; In acetone; for 48h; Heating;

DOI:10.1021/jm00121a034

upstream raw materials:

2,4-dibenzoyloxyacetophenone

2',4'-dihydroxy-4-acetophenone

benzoyl chloride

recorcinol

Downstream raw materials:

4-(4-benzoyloxy-2-hydroxyphenyl)-2,2-difluoro-6-phenyl-1,3,2-dioxaborine

Refernces

• 1、 Shaik, Jeelan Basha,Yeggoni, Daniel Pushparaju,Kandrakonda, Yelamanda Rao,Penumala, Mohan,Zinka, Raveendra Babu,Kotapati, Kasi Viswanath,Darla, Mark Manidhar,Ampasala, Dinakara Rao,Subramanyam, Rajagopal,Amooru, Damu Gangaiah. "Synthesis and biological evaluation of flavone-8-acrylamide derivatives as potential multi-target-directed anti Alzheimer agents and investigation of binding mechanism with acetylcholinesterase". . . Retrieved 2019/05/17.
• 2、 Wang,Liu,Zhang. "An Efficient One-Pot Synthesis and Anticancer Activity of 4'-Substituted Flavonoids". . p. 1036 - 1041. Retrieved 2018/07/06.