Technology Process of 2,3,4,5,6-Pentafluoro-benzenesulfonic acid (1S,8S,10R)-(4-aza-tricyclo[6.2.1.02,7]undeca-2,4,6-trien-10-yl) ester
There total 9 articles about 2,3,4,5,6-Pentafluoro-benzenesulfonic acid (1S,8S,10R)-(4-aza-tricyclo[6.2.1.02,7]undeca-2,4,6-trien-10-yl) ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 90.6 percent / diethyl ether / 0 °C
2: 1) acetic anhydride, 2) ammonia gas / 1) 30 min, 105 deg C, 2) in xylene
3: 70 percent / sulfuric acid / ethanol / Heating
4: 49.2 percent / n-butyllithium / 1,2-dimethoxy-ethane; hexane / 1) 0 deg C, 2) 1.5 h, roomtemp.
5: 82.5 percent / phosphorus oxychloride / 200 °C / in sealed tube
6: 84.7 percent / NaOCH3, H2 / 5percent palladium / charcoal / ethanol
7: 77.3 percent / sodium bicarbonate / H2O; acetone / 20 h / 150 °C / in sealed tube
8: n-butyllithium / tetrahydrofuran; hexane / 1) 0.5 h, 0 deg C, 2) 30 min
With
n-butyllithium; sulfuric acid; ammonia; hydrogen; sodium methylate; acetic anhydride; sodium hydrogencarbonate; trichlorophosphate;
palladium on activated charcoal;
In
tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; ethanol; hexane; water; acetone;
DOI:10.1021/jo00188a003
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 82.5 percent / phosphorus oxychloride / 200 °C / in sealed tube
2: 84.7 percent / NaOCH3, H2 / 5percent palladium / charcoal / ethanol
3: 77.3 percent / sodium bicarbonate / H2O; acetone / 20 h / 150 °C / in sealed tube
4: n-butyllithium / tetrahydrofuran; hexane / 1) 0.5 h, 0 deg C, 2) 30 min
With
n-butyllithium; hydrogen; sodium methylate; sodium hydrogencarbonate; trichlorophosphate;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; hexane; water; acetone;
DOI:10.1021/jo00188a003
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 70 percent / sulfuric acid / ethanol / Heating
2: 49.2 percent / n-butyllithium / 1,2-dimethoxy-ethane; hexane / 1) 0 deg C, 2) 1.5 h, roomtemp.
3: 82.5 percent / phosphorus oxychloride / 200 °C / in sealed tube
4: 84.7 percent / NaOCH3, H2 / 5percent palladium / charcoal / ethanol
5: 77.3 percent / sodium bicarbonate / H2O; acetone / 20 h / 150 °C / in sealed tube
6: n-butyllithium / tetrahydrofuran; hexane / 1) 0.5 h, 0 deg C, 2) 30 min
With
n-butyllithium; sulfuric acid; hydrogen; sodium methylate; sodium hydrogencarbonate; trichlorophosphate;
palladium on activated charcoal;
In
tetrahydrofuran; 1,2-dimethoxyethane; ethanol; hexane; water; acetone;
DOI:10.1021/jo00188a003
