Technology Process of (3E)-3-(bromomethylene)-1,2,2-trimethylcyclopentanecarboxylic acid
There total 3 articles about (3E)-3-(bromomethylene)-1,2,2-trimethylcyclopentanecarboxylic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
endo-3,4-dibromo-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one;
With
sodium isopropylate;
In
isopropyl alcohol;
for 0.5h;
Reflux;
Inert atmosphere;
With
sodium hydroxide;
In
water; isopropyl alcohol;
for 3h;
Inert atmosphere;
Reflux;
With
hydrogenchloride;
In
water;
Inert atmosphere;
DOI:10.1016/j.tet.2011.12.053
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: bromine; acetic acid / 8 h / 80 °C / Inert atmosphere
2.1: sodium isopropylate / isopropyl alcohol / 0.5 h / Reflux; Inert atmosphere
2.2: 3 h / Inert atmosphere; Reflux
2.3: Inert atmosphere
With
bromine; sodium isopropylate; acetic acid;
In
isopropyl alcohol;
DOI:10.1016/j.tet.2011.12.053
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: silver nitrate; sodium hydroxide / water / 0.08 h / Inert atmosphere
1.2: 0.5 h / Inert atmosphere
2.1: bromine; acetic acid / 8 h / 80 °C / Inert atmosphere
3.1: sodium isopropylate / isopropyl alcohol / 0.5 h / Reflux; Inert atmosphere
3.2: 3 h / Inert atmosphere; Reflux
3.3: Inert atmosphere
With
bromine; sodium isopropylate; silver nitrate; acetic acid; sodium hydroxide;
In
water; isopropyl alcohol;
DOI:10.1016/j.tet.2011.12.053
![endo-3,4-dibromo-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one](/Databaselist/images/loading.webp)
