C₅₇H₈₆N₁₂O₁₄

Base Information

• Chemical Name: C₅₇H₈₆N₁₂O₁₄
• CAS No.: 1367370-34-0
• Molecular Formula: C₅₇H₈₆N₁₂O₁₄
• Molecular Weight: 1163.38
• Mol file: 1367370-34-0.mol

Synonyms:

Chemical Property of C₅₇H₈₆N₁₂O₁₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₇H₈₆N₁₂O₁₄

There total 13 articles about C₅₇H₈₆N₁₂O₁₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N3(α-aminoisobutyric acid)4OtBu (1187839-02-6) → C57H86N12O14 (1367370-34-0)

Guidance literature:

Multi-step reaction with 5 steps

1: palladium on activated charcoal; hydrogen / methanol

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / Inert atmosphere

4: acetic anhydride / 2 h / 120 °C / Inert atmosphere

5: acetonitrile / 72 h / 90 °C / Inert atmosphere

With palladium on activated charcoal; hydrogen; acetic anhydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In methanol; dichloromethane; acetonitrile;

DOI:10.1039/c2cc00060a

Reference yield:

Cbz(L-Phe)(α-aminoisobutyric acid)4OtBu (1187839-07-1) → C57H86N12O14 (1367370-34-0)

Guidance literature:

Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / Inert atmosphere

2: acetic anhydride / 2 h / 120 °C / Inert atmosphere

3: acetonitrile / 72 h / 90 °C / Inert atmosphere

With acetic anhydride; trifluoroacetic acid; In dichloromethane; acetonitrile;

DOI:10.1039/c2cc00060a

Reference yield:

Tetrahydro-4H-pyran-4-one (29943-42-8,143562-54-3) → C57H86N12O14 (1367370-34-0)

Guidance literature:

Multi-step reaction with 6 steps

1.1: ethanol; water / 6 h / 60 °C / Inert atmosphere

2.1: water; potassium hydroxide / 16 h / 130 °C / Inert atmosphere

3.1: acetone / 79 h / 0 - 20 °C / Inert atmosphere

4.1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

4.2: 96 h / 0 - 20 °C / Inert atmosphere

5.1: palladium on activated charcoal; hydrogen / methanol

6.1: acetonitrile / 72 h / 90 °C / Inert atmosphere

With palladium on activated charcoal; water; hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In methanol; ethanol; dichloromethane; water; acetone; acetonitrile;

DOI:10.1039/c2cc00060a

upstream raw materials:

Tetrahydro-4H-pyran-4-one

8-oxa-1,3-diazaspiro[4.5]decane-2,4-dione

N₃(α-aminoisobutyric acid)₄OtBu

Cbz(L-Phe)(α-aminoisobutyric acid₎₄OtBu

Refernces