5-methyl-1-(phenylmethyl)-2-pyrrolidinone

Base Information

• Chemical Name: 5-methyl-1-(phenylmethyl)-2-pyrrolidinone
• CAS No.: 134415-21-7
• Molecular Formula: C₁₂H₁₅NO
• Molecular Weight: 189.257
• Mol file: 134415-21-7.mol

Synonyms:

Chemical Property of 5-methyl-1-(phenylmethyl)-2-pyrrolidinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-methyl-1-(phenylmethyl)-2-pyrrolidinone

There total 44 articles about 5-methyl-1-(phenylmethyl)-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-benzyl-5-hydroxy-5-methyl-pyrrolidin-2-one (17448-21-4) → 5-methyl-1-(phenylmethyl)-2-pyrrolidinone (91640-09-4,134415-21-7)

Guidance literature:

With 1% Pd on activated carbon; hydrogen; In tetrahydrofuran; at 50 ℃; for 2h; under 15201 Torr; Solvent; Temperature; Time;

DOI:10.1007/s11172-015-0945-z

Reference yield: 99.0%

levulinic acid (123-76-2) + benzylamine (100-46-9) → 5-methyl-1-(phenylmethyl)-2-pyrrolidinone (91640-09-4,134415-21-7)

Guidance literature:

With platinum on carbon; hydrogen; In methanol; at 25 ℃; for 3h;

DOI:10.1021/jacs.8b13024

Reference yield: 95.0%

4-oxopentanoic acid benzyl amide (17416-73-8) → 5-methyl-1-(phenylmethyl)-2-pyrrolidinone (91640-09-4,134415-21-7)

Guidance literature:

With hydrogenchloride; palladium on activated charcoal; hydrogen; In methanol; at 60 ℃; for 6h; under 15201 Torr; Solvent; Temperature; Reagent/catalyst; Inert atmosphere; Autoclave;

DOI:10.1007/s11172-015-0978-3

upstream raw materials:

methylmagnesium bromide

1-(phenylmethyl)-5-(phenylsulphonyl)-2-pyrrolidinone

1-(phenylmethyl)-2,5-pyrrolidinedione

1-benzyl-5-hydroxypyrrolidin-2-one

Downstream raw materials:

methyl 1-benzyl-5-methyl-2-oxopyrrolidine-3-carboxylate

1-benzyl-5-methyl-2-oxopyrrolidine-3-carboxylic acid

Refernces

• 1、 Gao, Guang,Sun, Peng,Li, Yunqin,Wang, Fang,Zhao, Zelun,Qin, Yong,Li, Fuwei. "Highly Stable Porous-Carbon-Coated Ni Catalysts for the Reductive Amination of Levulinic Acid via an Unconventional Pathway". . p. 4927 - 4935. Retrieved 2017.
• 2、 Wu, Cailing,Zhang, Hongye,Yu, Bo,Chen, Yu,Ke, Zhengang,Guo, Shien,Liu, Zhimin. "Lactate-Based Ionic Liquid Catalyzed Reductive Amination/Cyclization of Keto Acids under Mild Conditions: A Metal-Free Route to Synthesize Lactams". . p. 7772 - 7776. Retrieved 2017.
• 3、 -. "PYRROLIDINE AND BICYCLOHETEROARYL CONTAINING OGA INHIBITOR COMPOUNDS". Page/Page column 80. . Retrieved 2021/05/21.
• 4、 Raut, Amol B.,Shende, Vaishali S.,Sasaki, Takehiko,Bhanage, Bhalchandra M.. "Reductive amination of levulinic acid to N-substituted pyrrolidones over RuCl3 metal ion anchored in ionic liquid immobilized on graphene oxide". . p. 206 - 214. Retrieved 2020/02/15.