cis-4-nitrocyclohexanamine monohydrobromide

Base Information

• Chemical Name: cis-4-nitrocyclohexanamine monohydrobromide
• CAS No.: 130686-63-4
• Molecular Formula: BrH*C₆H₁₂N₂O₂
• Molecular Weight: 225.085
• Mol file: 130686-63-4.mol

Synonyms:

Chemical Property of cis-4-nitrocyclohexanamine monohydrobromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cis-4-nitrocyclohexanamine monohydrobromide

There total 7 articles about cis-4-nitrocyclohexanamine monohydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-hydroxycyclohexylamine (6850-65-3) → cis-4-nitrocyclohexanamine monohydrobromide (130686-63-4)

Guidance literature:

Multi-step reaction with 7 steps

1: 90 percent / NaHCO₃ / H₂O / 1.5 h / 45 °C

2: 81 percent / pyridinium chlorochromate / CHCl₃ / 48 h / Ambient temperature

3: 96 percent / NH₂OH*HCl, Na₂CO₃ / H₂O; methanol / 1 h / Ambient temperature

4: 100 percent / Cl₂ / CH₂Cl₂ / 0.08 h / 0 - 5 °C

5: 100 percent / O₃ / CH₂Cl₂ / 0.5 h

6: 41 percent / zinc, NH₂OH*HCl / H₂O; tetrahydrofuran / 60 °C

7: HBr / trifluoroacetic acid; diethyl ether / 0.5 h / Ambient temperature

With hydroxylamine hydrochloride; hydrogen bromide; chlorine; sodium hydrogencarbonate; sodium carbonate; ozone; pyridinium chlorochromate; zinc; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; chloroform; water; trifluoroacetic acid;

Reference yield:

(trans)-(4-hydroxy-cyclohexyl)-carbamic acid benzyl ester (27489-63-0,149423-75-6,16801-62-0) → cis-4-nitrocyclohexanamine monohydrobromide (130686-63-4)

Guidance literature:

Multi-step reaction with 6 steps

1: 81 percent / pyridinium chlorochromate / CHCl₃ / 48 h / Ambient temperature

2: 96 percent / NH₂OH*HCl, Na₂CO₃ / H₂O; methanol / 1 h / Ambient temperature

3: 100 percent / Cl₂ / CH₂Cl₂ / 0.08 h / 0 - 5 °C

4: 100 percent / O₃ / CH₂Cl₂ / 0.5 h

5: 41 percent / zinc, NH₂OH*HCl / H₂O; tetrahydrofuran / 60 °C

6: HBr / trifluoroacetic acid; diethyl ether / 0.5 h / Ambient temperature

With hydroxylamine hydrochloride; hydrogen bromide; chlorine; sodium carbonate; ozone; pyridinium chlorochromate; zinc; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; chloroform; water; trifluoroacetic acid;

Reference yield:

benzyl N-(4-oxocyclohexyl)carbamate (16801-63-1) → cis-4-nitrocyclohexanamine monohydrobromide (130686-63-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 96 percent / NH₂OH*HCl, Na₂CO₃ / H₂O; methanol / 1 h / Ambient temperature

2: 100 percent / Cl₂ / CH₂Cl₂ / 0.08 h / 0 - 5 °C

3: 100 percent / O₃ / CH₂Cl₂ / 0.5 h

4: 41 percent / zinc, NH₂OH*HCl / H₂O; tetrahydrofuran / 60 °C

5: HBr / trifluoroacetic acid; diethyl ether / 0.5 h / Ambient temperature

With hydroxylamine hydrochloride; hydrogen bromide; chlorine; sodium carbonate; ozone; zinc; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; trifluoroacetic acid;

upstream raw materials:

phenylmethyl (4-nitrocyclohexyl)carbamate

p-hydroxycyclohexylamine

benzyl N-(4-oxocyclohexyl)carbamate

(trans)-(4-hydroxy-cyclohexyl)-carbamic acid benzyl ester

Refernces