4-hydroxy-N,N,N-trimethyl-8-(phenylmethoxy)-3,5,10-trioxa-4-phosphahexacosan-1-aminium 4-oxide, hydroxide

Base Information

• Chemical Name: 4-hydroxy-N,N,N-trimethyl-8-(phenylmethoxy)-3,5,10-trioxa-4-phosphahexacosan-1-aminium 4-oxide, hydroxide
• CAS No.: 97150-20-4
• Molecular Formula: C₃₂H₆₀NO₆P
• Molecular Weight: 585.805
• Mol file: 97150-20-4.mol

Synonyms:

Chemical Property of 4-hydroxy-N,N,N-trimethyl-8-(phenylmethoxy)-3,5,10-trioxa-4-phosphahexacosan-1-aminium 4-oxide, hydroxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-hydroxy-N,N,N-trimethyl-8-(phenylmethoxy)-3,5,10-trioxa-4-phosphahexacosan-1-aminium 4-oxide, hydroxide

There total 7 articles about 4-hydroxy-N,N,N-trimethyl-8-(phenylmethoxy)-3,5,10-trioxa-4-phosphahexacosan-1-aminium 4-oxide, hydroxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-Hexadecanol (36653-82-4,124-29-8) → 4-hydroxy-N,N,N-trimethyl-8-(phenylmethoxy)-3,5,10-trioxa-4-phosphahexacosan-1-aminium 4-oxide, hydroxide (97150-20-4)

Guidance literature:

Multi-step reaction with 7 steps

1: 68 percent / NaH / toluene / 40 h / Heating

2: 93 percent / 1 M borane in THF / 2 h / 0 °C

3: 1.) oxalyl chloride, Me₂SO, 2.) Et₃N / 1.) CH₂Cl₂, -20 deg C, 20 min., 2.) CH₂Cl₂, -20 deg C to 25 deg C

4: 1.) Mg / 1.) THF, 2.) ether, 25 deg C, 1 h

5: 49 percent / NaH / dimethylformamide

6: 1.) BH₃, 2.) 3 N aq. NaOH, 30percent H₂O₂ / 1.) THF, 25 deg C, 3 h, 2.) H₂O, 25 deg C, 0.5 h

7: 1.) Et₃N, 2.) NaOAc

With sodium hydroxide; borane-THF; oxalyl dichloride; borane; dihydrogen peroxide; sodium acetate; sodium hydride; magnesium; dimethyl sulfoxide; triethylamine; In N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm00147a010

Reference yield:

2-(hexadecyloxy)ethanol (2136-71-2,39290-55-6,53663-60-8,8038-99-1,9004-95-9) → 4-hydroxy-N,N,N-trimethyl-8-(phenylmethoxy)-3,5,10-trioxa-4-phosphahexacosan-1-aminium 4-oxide, hydroxide (97150-20-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) oxalyl chloride, Me₂SO, 2.) Et₃N / 1.) CH₂Cl₂, -20 deg C, 20 min., 2.) CH₂Cl₂, -20 deg C to 25 deg C

2: 1.) Mg / 1.) THF, 2.) ether, 25 deg C, 1 h

3: 49 percent / NaH / dimethylformamide

4: 1.) BH₃, 2.) 3 N aq. NaOH, 30percent H₂O₂ / 1.) THF, 25 deg C, 3 h, 2.) H₂O, 25 deg C, 0.5 h

5: 1.) Et₃N, 2.) NaOAc

With sodium hydroxide; oxalyl dichloride; borane; dihydrogen peroxide; sodium acetate; sodium hydride; magnesium; dimethyl sulfoxide; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1021/jm00147a010

Reference yield:

2-(hexadecyloxy)acetaldehyde (60956-71-0) → 4-hydroxy-N,N,N-trimethyl-8-(phenylmethoxy)-3,5,10-trioxa-4-phosphahexacosan-1-aminium 4-oxide, hydroxide (97150-20-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) Mg / 1.) THF, 2.) ether, 25 deg C, 1 h

2: 49 percent / NaH / dimethylformamide

3: 1.) BH₃, 2.) 3 N aq. NaOH, 30percent H₂O₂ / 1.) THF, 25 deg C, 3 h, 2.) H₂O, 25 deg C, 0.5 h

4: 1.) Et₃N, 2.) NaOAc

With sodium hydroxide; borane; dihydrogen peroxide; sodium acetate; sodium hydride; magnesium; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1021/jm00147a010

upstream raw materials:

2-bromoethylphosphoric acid dichloride

4-(hexadecyloxy)-3-(phenylmethoxy)-1-butanol

trimethylamine

1-Hexadecanol

Refernces