N,2-dimethyl-4-nitrobenzenesulfonamide

Base Information

• Chemical Name: N,2-dimethyl-4-nitrobenzenesulfonamide
• CAS No.: 106840-80-6
• Molecular Formula: C₈H₁₀N₂O₄S
• Molecular Weight: 230.244
• Mol file: 106840-80-6.mol

Synonyms:

Chemical Property of N,2-dimethyl-4-nitrobenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,2-dimethyl-4-nitrobenzenesulfonamide

There total 5 articles about N,2-dimethyl-4-nitrobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-mercapto-3-methyl-1-nitrobenzene (497855-56-8) → N,2-dimethyl-4-nitrobenzenesulfonamide (106840-80-6)

Guidance literature:

Multi-step reaction with 3 steps

1: dihydrogen peroxide; acetic acid / 2 h / Reflux

2: thionyl chloride / 5 h / Reflux

3: ethanol / 5 h / 20 °C

With thionyl chloride; dihydrogen peroxide; acetic acid; In ethanol;

DOI:10.1002/anie.201510236

Reference yield:

2-methyl-4-nitrobenzenesulfonic acid (7434-70-0) → N,2-dimethyl-4-nitrobenzenesulfonamide (106840-80-6)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 5 h / Reflux

2: ethanol / 5 h / 20 °C

With thionyl chloride; In ethanol;

DOI:10.1002/anie.201510236

Reference yield:

1-chloro-2-methyl-4-nitrobenzene (13290-74-9) → N,2-dimethyl-4-nitrobenzenesulfonamide (106840-80-6)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium sulfide; sulfur; sodium hydroxide / ethanol / 10 h / Reflux

2: dihydrogen peroxide; acetic acid / 2 h / Reflux

3: thionyl chloride / 5 h / Reflux

4: ethanol / 5 h / 20 °C

With sodium sulfide; thionyl chloride; dihydrogen peroxide; sulfur; acetic acid; sodium hydroxide; In ethanol;

DOI:10.1002/anie.201510236

upstream raw materials:

1-chloro-2-methyl-4-nitrobenzene

4-mercapto-3-methyl-1-nitrobenzene

2-methyl-4-nitrobenzenesulfonic acid

5-nitro-2-toluenesulfonyl chloride

Refernces

• 1、 PETROW,STEPHENSON,WILD. "Studies in the field of diuretic agents. V. A new route to disulphamyl derivatives of benzene.". . p. 705 - 719. Retrieved 2007/10/04.