C₂₀H₂₆N₅O₂BrSi

Base Information

• Chemical Name: C₂₀H₂₆N₅O₂BrSi
• CAS No.: 948834-70-6
• Molecular Formula: C₂₀H₂₆BrN₅O₂Si
• Molecular Weight: 476.448
• Mol file: 948834-70-6.mol

Synonyms:

Chemical Property of C₂₀H₂₆N₅O₂BrSi

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₂₆N₅O₂BrSi

There total 5 articles about C₂₀H₂₆N₅O₂BrSi which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

5-bromo-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid (916325-85-4) + 3-(tert-butyl-dimethyl-silanyloxymethyl)-benzene-1,2-diamine (916326-41-5) → C20H26N5O2BrSi (948834-70-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2007.05.029

Reference yield:

pyrazolo[3,4-b]pyridine-3-carboxylic acid methyl ester (916325-83-2) → C20H26N5O2BrSi (948834-70-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 43 percent / Br₂; NaOAc; acetic acid / 115 °C

2: 100 percent / aq. NaOH / methanol / 4 h / Heating

3: 61 percent / HATU; DIPEA / dimethylformamide

With sodium hydroxide; bromine; sodium acetate; acetic acid; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2007.05.029

Reference yield:

methyl 5-bromo-1H-pyrazolo[3,4-b]pyridine-3-carboxylate (916325-84-3) → C20H26N5O2BrSi (948834-70-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / aq. NaOH / methanol / 4 h / Heating

2: 61 percent / HATU; DIPEA / dimethylformamide

With sodium hydroxide; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2007.05.029

upstream raw materials:

5-bromo-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid

3-(tert-butyl-dimethyl-silanyloxymethyl)-benzene-1,2-diamine

pyrazolo[3,4-b]pyridine-3-carboxylic acid methyl ester

methyl 5-bromo-1H-pyrazolo[3,4-b]pyridine-3-carboxylate

Refernces