4-[(3-fluorobenzyl)oxy]benzoyl chloride

Base Information

• Chemical Name: 4-[(3-fluorobenzyl)oxy]benzoyl chloride
• CAS No.: 1160250-86-1
• Molecular Formula: C₁₄H₁₀ClFO₂
• Molecular Weight: 264.684
• Mol file: 1160250-86-1.mol

Synonyms:

Chemical Property of 4-[(3-fluorobenzyl)oxy]benzoyl chloride

Chemical Property:

• Boiling Point: 381.9±22.0 °C(Predicted)
• Density: 1.292±0.06 g/cm3(Predicted)

Purity/Quality:

98%min ^*data from raw suppliers

4-[(3-Fluorobenzyl)oxy]benzoyl chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[(3-fluorobenzyl)oxy]benzoyl chloride

There total 4 articles about 4-[(3-fluorobenzyl)oxy]benzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(3-fluorobenzyloxy)benzoic acid (405-85-6) → C14H10ClFO2 (1160250-86-1)

Guidance literature:

With pyridine; thionyl chloride; In toluene; at 72 ℃; for 6h;

DOI:10.1039/c5md00092k

Reference yield:

methyl 4-hydroxylbenzoate (99-76-3,156291-94-0) → C14H10ClFO2 (1160250-86-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / acetone / 5 h / 65 - 80 °C

2.1: sodium hydroxide; water / methanol / 2 h / 75 °C

2.2: pH 5

3.1: pyridine; thionyl chloride / toluene / 6 h / 72 °C

With pyridine; thionyl chloride; water; potassium carbonate; sodium hydroxide; In methanol; acetone; toluene;

DOI:10.1039/c5md00092k

Reference yield:

1-(Bromomethyl)-3-fluorobenzene (456-41-7) → C14H10ClFO2 (1160250-86-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / acetone / 5 h / 65 - 80 °C

2.1: sodium hydroxide; water / methanol / 2 h / 75 °C

2.2: pH 5

3.1: pyridine; thionyl chloride / toluene / 6 h / 72 °C

With pyridine; thionyl chloride; water; potassium carbonate; sodium hydroxide; In methanol; acetone; toluene;

DOI:10.1039/c5md00092k

upstream raw materials:

methyl 4-hydroxylbenzoate

1-(Bromomethyl)-3-fluorobenzene

methyl 4-[(3-fluorobenzyl)oxy]benzoate

4-(3-fluorobenzyloxy)benzoic acid

Refernces

• 1、 Sun, Chiyu,Li, Yangsheng,Shi, Ailong,Zhang, Jingzhou,Li, Yafei,Zhao, Mingming,Zhang, Lijuan,Zheng, Huachuan,Meng, Ying,Ding, Huaiwei,Song, Hongrui. "Synthesis and evaluation of novel N-3-benzimidazolephenylbisamide derivatives for antiproliferative and Hedgehog pathway inhibitory activity". . p. 1137 - 1142. Retrieved 2015/06/25.