3-Furancarboxylic acid, 2-[[5-[3-[2-(2-quinolinyl)ethenyl]phenyl]-2H-tetrazol-2-yl]methyl]-, methyl ester, (E)-

Base Information

• Chemical Name: 3-Furancarboxylic acid, 2-[[5-[3-[2-(2-quinolinyl)ethenyl]phenyl]-2H-tetrazol-2-yl]methyl]-, methyl ester, (E)-
• CAS No.: 138813-31-7
• Molecular Formula: C25H19N5O3
• Molecular Weight: 437.458
• Mol file: 138813-31-7.mol

Synonyms:

Chemical Property of 3-Furancarboxylic acid, 2-[[5-[3-[2-(2-quinolinyl)ethenyl]phenyl]-2H-tetrazol-2-yl]methyl]-, methyl ester, (E)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Furancarboxylic acid, 2-[[5-[3-[2-(2-quinolinyl)ethenyl]phenyl]-2H-tetrazol-2-yl]methyl]-, methyl ester, (E)-

There total 3 articles about 3-Furancarboxylic acid, 2-[[5-[3-[2-(2-quinolinyl)ethenyl]phenyl]-2H-tetrazol-2-yl]methyl]-, methyl ester, (E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-bromomethylfuran-3-carboxylic acid methyl ester (53020-08-9) + 2-<2-<3-(2H-tetrazol-5-yl)phenyl>ethenyl>quinoline (138813-28-2) → 2-<<5-<3-(2-quinolin-2-ylethenyl)phenyl>-2H-tetrazol-2-yl>methyl>-3-furancarboxylic acid methyl ester (138813-31-7)

Guidance literature:

With potassium carbonate; potassium iodide; In butanone; for 8h; Heating;

DOI:10.1021/jm00085a005

Reference yield:

2-<2-(3-cyanophenyl)ethenyl>quinoline (138786-13-7) → 2-<<5-<3-(2-quinolin-2-ylethenyl)phenyl>-2H-tetrazol-2-yl>methyl>-3-furancarboxylic acid methyl ester (138813-31-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / LiN₃, triethylammonium bromide / 2-methoxy-ethanol / 3 h / 120 °C

2: 72 percent / K₂CO₃, KI / butan-2-one / 8 h / Heating

With lithium azide; triethylamine hydrobromide; potassium carbonate; potassium iodide; In 2-methoxy-ethanol; butanone;

DOI:10.1021/jm00085a005

Reference yield:

quinolin-2-ylmethyl-triphenylphosphonium chloride (99651-30-6) → 2-<<5-<3-(2-quinolin-2-ylethenyl)phenyl>-2H-tetrazol-2-yl>methyl>-3-furancarboxylic acid methyl ester (138813-31-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) n-BuLi / 1.) THF, hexane, RT, 0.5 h, 2.) THF, hexane, RT, 5 h

2: 82 percent / LiN₃, triethylammonium bromide / 2-methoxy-ethanol / 3 h / 120 °C

3: 72 percent / K₂CO₃, KI / butan-2-one / 8 h / Heating

With n-butyllithium; lithium azide; triethylamine hydrobromide; potassium carbonate; potassium iodide; In 2-methoxy-ethanol; butanone;

DOI:10.1021/jm00085a005

upstream raw materials:

2-bromomethylfuran-3-carboxylic acid methyl ester

2-<2-<3-(2H-tetrazol-5-yl)phenyl>ethenyl>quinoline

2-<2-(3-cyanophenyl)ethenyl>quinoline

quinolin-2-ylmethyl-triphenylphosphonium chloride

Downstream raw materials:

2-{5-[3-((E)-2-Quinolin-2-yl-vinyl)-phenyl]-tetrazol-2-ylmethyl}-furan-3-carboxylic acid

Refernces