nortropyl α-phenylcyclopentylacetate

Base Information

• Chemical Name: nortropyl α-phenylcyclopentylacetate
• CAS No.: 437762-18-0
• Molecular Formula: C₂₀H₂₇NO₂
• Molecular Weight: 313.44
• Mol file: 437762-18-0.mol

Synonyms:

Chemical Property of nortropyl α-phenylcyclopentylacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of nortropyl α-phenylcyclopentylacetate

There total 4 articles about nortropyl α-phenylcyclopentylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-cyclopentyl-2-phenylacetic acid (3900-93-4) → nortropyl α-phenylcyclopentylacetate (437762-18-0,47271-49-8,47271-50-1)

Guidance literature:

Multi-step reaction with 4 steps

1: thionyl chloride; N,N-dimethylformamide / diethyl ether / 2 h / Heating

2: 2.5 g / nitromethane / 24 h / Heating

3: 1,2-dichloro-ethane / 1 h / Heating

4: 0.95 g / methanol / 0.75 h

With thionyl chloride; N,N-dimethyl-formamide; In methanol; diethyl ether; nitromethane; 1,2-dichloro-ethane;

Reference yield:

(1R,3R,5S)-3-(2-Cyclopentyl-2-phenyl-acetoxy)-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid 1-chloro-ethyl ester (437762-21-5) → nortropyl α-phenylcyclopentylacetate (437762-18-0,47271-49-8,47271-50-1)

Guidance literature:

In methanol; for 0.75h;

Reference yield:

α-phenylcyclopentaneacetyl chloride (7037-44-7) → nortropyl α-phenylcyclopentylacetate (437762-18-0,47271-49-8,47271-50-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 2.5 g / nitromethane / 24 h / Heating

2: 1,2-dichloro-ethane / 1 h / Heating

3: 0.95 g / methanol / 0.75 h

In methanol; nitromethane; 1,2-dichloro-ethane;

upstream raw materials:

(1R,3R,5S)-3-(2-Cyclopentyl-2-phenyl-acetoxy)-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid 1-chloro-ethyl ester

α-phenylcyclopentaneacetyl chloride

2-cyclopentyl-2-phenylacetic acid

tropyl α-phenylcyclopentylacetate

Downstream raw materials:

methoxycarbonylmethylnortropyl N_α-phenylcyclopentylacetate

ethoxycarbonylmethylnortropyl N_α-phenylcyclopentylacetate

Refernces