N-hydroxyvalinamide

Base Information

• Chemical Name: N-hydroxyvalinamide
• CAS No.: 28664-96-2
• Molecular Formula: C₅H₁₂N₂O₂
• Molecular Weight: 132.162
• Mol file: 28664-96-2.mol

Synonyms:Butanamide,2-amino-N-hydroxy-3-methyl-, (S)-; Butyrohydroxamic acid, 2-amino-3-methyl-, L-(8CI); L-Valine hydroxamic acid; NSC 215122

Chemical Property of N-hydroxyvalinamide

Chemical Property:

• Density: 1.111g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-hydroxyvalinamide

There total 3 articles about N-hydroxyvalinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(S)-Nα-(benzyloxycarbonyl)valine hydroxamic acid → L-valine hydroxamate (28664-96-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 7h;

DOI:10.1002/chem.200900548

Reference yield:

L-valine methyl ester (4070-48-8) → DL-valine hydroxamic acid (36207-48-4,28664-96-2)

Guidance literature:

With methanol; hydroxylamine; at 0 ℃;

Reference yield:

L-valine ethyl ester (17431-03-7) → L-valine hydroxamate (28664-96-2)

Guidance literature:

With hydroxyamino hydrochloride; sodium hydroxide; In methanol; at 0 - 20 ℃;

DOI:10.1039/d1dt02604f

upstream raw materials:

L-valine methyl ester

L-valine ethyl ester

Refernces

• 1、 Ahlford, Katrin,Ekstr?m, Jesper,Zaitsev, Alexey B.,Ryberg, Per,Eriksson, Lars,Adolfsson, Hans. "Asymmetrie transfer hydrogenation of ketones catalyzed by amino acid derived rhodium complexes: on the origin of enantioselectivity and enantioswitchability". supporting information; experimental part. p. 11197 - 11209. Retrieved 2010/04/26.