2,3,4,5-Tetramethylthiophene

Base Information

• Chemical Name: 2,3,4,5-Tetramethylthiophene
• CAS No.: 14503-51-6
• Molecular Formula: C8H12 S
• Molecular Weight: 140.249
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID60162870
• Nikkaji Number: J509.152G
• Wikidata: Q83031628
• Mol file: 14503-51-6.mol

Synonyms:2,3,4,5-tetramethylthiophene;14503-51-6;tetramethylthiophene;Thiophene,tetramethyl-;Thiophene, tetramethyl-;Thiophene, 2,3,4,5-tetramethyl-;SCHEMBL115557;2,3,4,5-Tetramethyl-thiophene;DTXSID60162870;GEO-02283;MFCD07368974;AKOS005255894;FT-0609355;W-200115

Chemical Property of 2,3,4,5-Tetramethylthiophene

Chemical Property:

• Vapor Pressure: 0.501mmHg at 25°C
• Boiling Point: 198.7°Cat760mmHg
• Flash Point: 51.4°C
• PSA: 28.24000
• Density: 0.973g/cm³
• LogP: 2.98170
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 140.06597156
• Heavy Atom Count: 9
• Complexity: 88.7

Purity/Quality:

99%, ^*data from raw suppliers

2,3,4,5-TETRAMETHYLTHIOPHENE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(SC(=C1C)C)C

Technology Process of 2,3,4,5-Tetramethylthiophene

There total 21 articles about 2,3,4,5-Tetramethylthiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2,3,4,5-Tetramethyl-tetrahydro-thiophene-3,4-diol (100990-27-0,111691-81-7) → tetramethylthiophene (14503-51-6)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; Heating;

DOI:10.1016/S0040-4039(00)98358-8

Reference yield: 56.0%

3,4-bis(chloromethyl)-2,5-dimethylthiophene (5368-70-7) → tetramethylthiophene (14503-51-6)

Guidance literature:

With LiAH; In diethyl ether;

DOI:10.1039/a900190e

Reference yield: 44.0%

2,3,4,5-tetramethylfuran (10599-58-3) → tetramethylthiophene (14503-51-6)

Guidance literature:

With hydrogenchloride; hydrogen sulfide; at 35 ℃;

DOI:10.1007/BF00471795

upstream raw materials:

2-iodo-3,4,5-trimethyl-thiophene

methyl iodide

2,4,5-trimethyl-thiophene-3-carbaldehyde

3,4-bis(chloromethyl)-2,5-dimethylthiophene

Downstream raw materials:

3,4,5,6-tetramethyl-1,2-benzenedicarbonitrile

1,3,4,5-tetramethyl-2-thia-bicyclo[3.2.0]hepta-3,6-diene-6,7-dicarbonitrile

Tetramethylphthalsaeure-dimethylester

thiophene

Refernces

• 1、 Schmid, Ralf,Goebel, Friederike,Warnecke, Andre,Labahn, Andreas. "Synthesis and redox potentials of methylated vitamin K derivatives". . p. 1199 - 1202. Retrieved 2007/10/03.
• 2、 Yoshida, Kunihisa,Takeda, Kazusada,Fueno, Takayuki. "Anodic Methoxylation of 2,5-Dimethyl- and Tetramethyl-thiophene. Formation and Transformation of 2,5-Dimethoxy Adducts". . p. 2817 - 2820. Retrieved 2007/10/02.