DiMethoxy Dienogest

Base Information

• Chemical Name: DiMethoxy Dienogest
• CAS No.: 102193-41-9
• Molecular Formula: C₂₂H₃₁NO₃
• Molecular Weight: 357.493
• Mol file: 102193-41-9.mol

Synonyms:

Chemical Property of DiMethoxy Dienogest

Chemical Property:

• Melting Point: 79-83°C
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly), Pyridine (Slightly)

Purity/Quality:

HPLC ≥ 98% ^*data from raw suppliers

DimethoxyDienogest ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Dimethoxy Dienogest is an impurity of Dienogest (D441870), a derivative of 19-Nortestosterone (N315000) and an oral contraceptive used in combination with estrogen.

Technology Process of DiMethoxy Dienogest

There total 1 articles about DiMethoxy Dienogest which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,3-dimethoxy-estra-5(10),9(11)-diene-17-one (10109-76-9) + acetonitrile (75-05-8,26809-02-9) → 3,3-dimethoxy-17α-cyanomethyl-17β-hydroxy-estra-5(10),9(11)-diene (102193-41-9)

Guidance literature:

3,3-dimethoxy-estra-5⁽¹⁰⁾,9⁽¹¹⁾-diene-17-one; acetonitrile; With n-hexyllithium; In tetrahydrofuran; hexane; at -50 - -40 ℃; for 1.5h;

With water; In tetrahydrofuran; hexane; at -10 - 0 ℃;

Reference yield:

3,3-dimethoxy-17α-cyanomethyl-17β-hydroxy-estra-5(10),9(11)-diene (102193-41-9) → 17α-Cyanomethyl-17β-hydroxy-estra-5(10),9(11)-dien-3-on (106111-42-6)

Guidance literature:

With oxalic acid; at 20 - 30 ℃;

Reference yield:

3,3-dimethoxy-17α-cyanomethyl-17β-hydroxy-estra-5(10),9(11)-diene (102193-41-9) → 17α-Cyanomethyl-17β-hydroxy-estra-5(10),9(11)-dien-3-on (106111-42-6) + Dienogest (65928-58-7)

Guidance literature:

With sulfuric acid; In water; acetonitrile; at 20 - 30 ℃; Reagent/catalyst; Solvent;

upstream raw materials:

3,3-dimethoxy-estra-5⁽¹⁰⁾,9⁽¹¹⁾-diene-17-one

acetonitrile

Downstream raw materials:

17α-Cyanomethyl-17β-hydroxy-estra-5(10),9(11)-dien-3-on

Dienogest

Refernces

• 1、 -. "PROCESS FOR THE PREPARATION OF DIENOGEST SUBSTANTIALLY FREE OF IMPURITIES". Page/Page column 9. . Retrieved 2011/11/06.