Sodium; (2-amino-3-benzoyl-5-fluoro-phenyl)-acetate

Base Information

• Chemical Name: Sodium; (2-amino-3-benzoyl-5-fluoro-phenyl)-acetate
• CAS No.: 91714-78-2
• Molecular Formula: C₁₅H₁₁FNO₃*Na
• Molecular Weight: 295.245
• Mol file: 91714-78-2.mol

Synonyms:

Chemical Property of Sodium; (2-amino-3-benzoyl-5-fluoro-phenyl)-acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Sodium; (2-amino-3-benzoyl-5-fluoro-phenyl)-acetate

There total 5 articles about Sodium; (2-amino-3-benzoyl-5-fluoro-phenyl)-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

7-Benzoyl-5-fluoro-1,3-dihydro-indol-2-one (91713-73-4) → Sodium; (2-amino-3-benzoyl-5-fluoro-phenyl)-acetate (91714-78-2)

Guidance literature:

With sodium hydroxide; for 18h; Heating;

DOI:10.1021/jm00377a001

Reference yield:

5-fluoro-2-aminobenzophenone (362-46-9) → Sodium; (2-amino-3-benzoyl-5-fluoro-phenyl)-acetate (91714-78-2)

Guidance literature:

Multi-step reaction with 5 steps

1: tert-butyl hypochlorite / CH₂Cl₂ / 1 h / -70 °C

2: Et₃N / CH₂Cl₂ / -70 - 20 °C

3: 3N aq. HCl / CH₂Cl₂ / 2 h / Heating

4: 82 percent / Raney nickel / tetrahydrofuran / 0.17 h

5: 41 percent / 3N aq. NaOH / 18 h / Heating

With hydrogenchloride; sodium hydroxide; tert-butylhypochlorite; nickel; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm00377a001

Reference yield:

7-Benzoyl-5-fluoro-3-methylsulfanyl-1,3-dihydro-indol-2-one (91713-72-3) → Sodium; (2-amino-3-benzoyl-5-fluoro-phenyl)-acetate (91714-78-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / Raney nickel / tetrahydrofuran / 0.17 h

2: 41 percent / 3N aq. NaOH / 18 h / Heating

With sodium hydroxide; nickel; In tetrahydrofuran;

DOI:10.1021/jm00377a001

upstream raw materials:

7-Benzoyl-5-fluoro-1,3-dihydro-indol-2-one

5-fluoro-2-aminobenzophenone

7-Benzoyl-5-fluoro-3-methylsulfanyl-1,3-dihydro-indol-2-one

Refernces