1-chloro-1-phenoxy-2-cyanocyclopropane

Base Information

• Chemical Name: 1-chloro-1-phenoxy-2-cyanocyclopropane
• CAS No.: 82849-48-7
• Molecular Formula: C₁₀H₈ClNO
• Molecular Weight: 193.633
• Mol file: 82849-48-7.mol

Synonyms:

Chemical Property of 1-chloro-1-phenoxy-2-cyanocyclopropane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-chloro-1-phenoxy-2-cyanocyclopropane

There total 5 articles about 1-chloro-1-phenoxy-2-cyanocyclopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

3-chloro-3-phenoxy-3H-diazirine (82849-43-2) + acrylonitrile (107-13-1,25014-41-9) → 1-chloro-1-phenoxy-2-cyanocyclopropane (82849-48-7)

Guidance literature:

In pentane; at 25 ℃; for 72h; sealed tube, in the dark;

DOI:10.1021/jo00143a001

Reference yield:

N-hydroxyl-O-phenylisourea (3174-90-1) → 1-chloro-1-phenoxy-2-cyanocyclopropane (82849-48-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 47 percent / aq. NaOH / H₂O / 1.) 13 deg C, 30 min, 2.) 25 deg C, 45 min

2: 37 percent / LiCl, DMSO, satd. aq. NaCl in 11percent aq. NaOCl / pentane / 0.83 h / -5 °C

3: 30 percent / pentane / 72 h / 25 °C / sealed tube, in the dark

With sodium hydroxide; sodium hypochlorite; dimethyl sulfoxide; lithium chloride; sodium chloride; In water; pentane;

DOI:10.1021/jo00143a001

Reference yield:

N-(benzenesulfonyloxy)-O-phenylisourea (3170-96-5) → 1-chloro-1-phenoxy-2-cyanocyclopropane (82849-48-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 37 percent / LiCl, DMSO, satd. aq. NaCl in 11percent aq. NaOCl / pentane / 0.83 h / -5 °C

2: 30 percent / pentane / 72 h / 25 °C / sealed tube, in the dark

With sodium hypochlorite; dimethyl sulfoxide; lithium chloride; sodium chloride; In pentane;

DOI:10.1021/jo00143a001

upstream raw materials:

3-chloro-3-phenoxy-3H-diazirine

acrylonitrile

N-hydroxyl-O-phenylisourea

N-(benzenesulfonyloxy)-O-phenylisourea

Refernces