9α-fluoro-11β,17α-dihydroxy-16α-methyl-3,20-dioxopregna-1,4-dien-21-yl β-D-galactopyranoside

Base Information

• Chemical Name: 9α-fluoro-11β,17α-dihydroxy-16α-methyl-3,20-dioxopregna-1,4-dien-21-yl β-D-galactopyranoside
• CAS No.: 92901-23-0
• Molecular Formula: C₂₈H₃₉FO₁₀
• Molecular Weight: 554.61
• Mol file: 92901-23-0.mol

Synonyms:

Chemical Property of 9α-fluoro-11β,17α-dihydroxy-16α-methyl-3,20-dioxopregna-1,4-dien-21-yl β-D-galactopyranoside

Chemical Property:

• Boiling Point: 778.9±60.0 °C(Predicted)
• Density: 1.45±0.1 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9α-fluoro-11β,17α-dihydroxy-16α-methyl-3,20-dioxopregna-1,4-dien-21-yl β-D-galactopyranoside

There total 4 articles about 9α-fluoro-11β,17α-dihydroxy-16α-methyl-3,20-dioxopregna-1,4-dien-21-yl β-D-galactopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

9α-fluoro-11β,17α-dihydroxy-16α-methyl-3,20-dioxopregna-1,4-dien-21-yl 2,3,4,6-tetra-O-acetyl-β-D-galactopyranoside (92901-30-9) → 9α-fluoro-11β,17α-dihydroxy-16α-methyl-3,20-dioxopregna-1,4-dien-21-yl β-D-galactopyranoside (92901-23-0,319426-57-8)

Guidance literature:

With sodium hydroxide; In methanol; benzene; for 0.75h; Ambient temperature;

DOI:10.1021/jm00379a012

Reference yield: 39.0%

dexamethasone (50-02-2) + 1-bromo-1-deoxy-2,3,4,6-tetra-O-acetyl-a-D-galactopyranoside (3068-32-4) → 9α-fluoro-11β,17α-dihydroxy-16α-methyl-3,20-dioxopregna-1,4-dien-21-yl β-D-galactopyranoside (92901-23-0,319426-57-8)

Guidance literature:

dexamethasone; 1-bromo-1-deoxy-2,3,4,6-tetra-O-acetyl-a-D-galactopyranoside; With 2,4,6-trimethyl-pyridine; silver trifluoromethanesulfonate; molecular sieve, 3 A; In dichloromethane; acetonitrile; for 20h;

sodium methylate; In methanol;

Reference yield:

dexamethasone (50-02-2) → 9α-fluoro-11β,17α-dihydroxy-16α-methyl-3,20-dioxopregna-1,4-dien-21-yl β-D-galactopyranoside (92901-23-0,319426-57-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 26 percent / Ag₂CO₃ / CHCl₃ / 1 h / Heating

2: 60 percent / NaOH / methanol; benzene / 0.75 h / Ambient temperature

With sodium hydroxide; silver carbonate; In methanol; chloroform; benzene;

DOI:10.1021/jm00379a012

upstream raw materials:

9α-fluoro-11β,17α-dihydroxy-16α-methyl-3,20-dioxopregna-1,4-dien-21-yl 2,3,4,6-tetra-O-acetyl-β-D-galactopyranoside

dexamethasone

1-bromo-1-deoxy-2,3,4,6-tetra-O-acetyl-a-D-galactopyranoside

Refernces

• 1、 -. "Compositions and methods for targeted enzymatic release of cell regulatory compounds". Page column 15. . Retrieved 2010/02/05.