3-phenylhexanoic acid methyl ester

Base Information

• Chemical Name: 3-phenylhexanoic acid methyl ester
• CAS No.: 861659-75-8
• Molecular Formula: C₁₃H₁₈O₂
• Molecular Weight: 206.285
• Mol file: 861659-75-8.mol

Synonyms:

Chemical Property of 3-phenylhexanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-phenylhexanoic acid methyl ester

There total 4 articles about 3-phenylhexanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl (E)-hex-2-enoate (13894-63-8) + phenyl trimethylsiloxane (2996-92-1,46143-12-8) → 3-phenylhexanoic acid methyl ester (861659-75-8) + 3-phenylhexanoic acid methyl ester

Guidance literature:

With (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine); bis(acetonitrile)(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; In 1,4-dioxane; water; at 90 ℃; for 20h; Title compound not separated from byproducts;

DOI:10.1016/j.tetasy.2005.12.032

Reference yield:

methyl (E)-hex-2-enoate (13894-63-8) + phenylboronic acid (98-80-6) → 3-phenylhexanoic acid methyl ester (861659-75-8) + 3-phenylhexanoic acid methyl ester

Guidance literature:

(R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; benzene; In 1,4-dioxane; water; Title compound not separated from byproducts; Heating;

DOI:10.1021/ol050834s

Reference yield:

methyl (E)-hex-2-enoate (13894-63-8) + phenyllithium (591-51-5) → 3-phenylhexanoic acid methyl ester (861659-75-8) + 3-phenylhexanoic acid methyl ester

Guidance literature:

phenyllithium; With Trimethyl borate; In diethyl ether; hexane; at -78 - -20 ℃; for 1.5h;

methyl (E)-hex-2-enoate; With bis(ethylene)rhodium acetylacetonate; (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine); In 1,4-dioxane; diethyl ether; water; at 100 ℃; for 3h; Title compound not separated from byproducts;

DOI:10.1016/S0957-4166(99)00417-6

upstream raw materials:

diazomethane

(3S)-3-phenylheptanoic acid

methyl (E)-hex-2-enoate

phenyllithium

Downstream raw materials:

rac.-Di-(o-anisyl)-3-phenyl-hexanol-⁽¹⁾

Refernces

• 1、 Ogasawara, Masamichi,Ngo, Helen L.,Sakamoto, Takeshi,Takahashi, Tamotsu,Lin, Wenbin. "Applications of 4,4′-Me3Si2-BINAP in transition-metal-catalyzed asymmetric carbon-carbon bond-forming reactions". . p. 2881 - 2884. Retrieved 2007/10/03.