5-fluoro-6-methoxy-2,3-dihydro-1H-indene

Base Information

• Chemical Name: 5-fluoro-6-methoxy-2,3-dihydro-1H-indene
• CAS No.: 83802-72-6
• Molecular Formula: C₁₀H₁₁FO
• Molecular Weight: 166.195
• DSSTox Substance ID: DTXSID801277369
• Mol file: 83802-72-6.mol

Synonyms:83802-72-6;5-fluoro-6-methoxy-2,3-dihydro-1H-indene;1H-Indene, 5-fluoro-2,3-dihydro-6-methoxy-;SCHEMBL23674495;WLZ3298;DTXSID801277369;BS-47908;5-Fluoro-2,3-dihydro-6-methoxy-1H-indene;F77123

Chemical Property of 5-fluoro-6-methoxy-2,3-dihydro-1H-indene

Chemical Property:

• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 166.079393132
• Heavy Atom Count: 12
• Complexity: 160

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=C(C=C2CCCC2=C1)F

Technology Process of 5-fluoro-6-methoxy-2,3-dihydro-1H-indene

There total 2 articles about 5-fluoro-6-methoxy-2,3-dihydro-1H-indene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

5-fluoro-6-methoxy-2,3-dihydro-1H-inden-1-one (83802-71-5) → 6-fluoro-5-methoxyindan (83802-72-6)

Guidance literature:

With methanesulfonic acid; palladium 10% on activated carbon; hydrogen; In ethanol; at 25 ℃; for 4h;

Reference yield:

3-(3-fluoro-4-methoxyphenyl)propionyl chloride (83802-70-4) → 6-fluoro-5-methoxyindan (83802-72-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / AlCl₃ / CS₂ / 1 h / 0 - 10 °C

2: 92 percent / Hg-Zn, concd. HCl / H₂O; toluene / 6 h / Heating

With hydrogenchloride; aluminium trichloride; mercury; zinc; In carbon disulfide; water; toluene;

DOI:10.1021/jm00356a024

Reference yield: 88.0%

6-fluoro-5-methoxyindan (83802-72-6) → 6-fluoro-5-indanol (83802-73-7)

Guidance literature:

With boron tribromide; In dichloromethane; at 0 - 20 ℃; for 3h;

DOI:10.1021/jm00356a024

upstream raw materials:

5-fluoro-6-methoxy-2,3-dihydro-1H-inden-1-one

3-(3-fluoro-4-methoxyphenyl)propionyl chloride

Downstream raw materials:

6-fluoro-5-indanol

6-fluoro-4-nitro-2,3-dihydro-1H-inden-5-ol

6-fluoro-4-nitro-5-(prop-1-en-2-yl)-2,3-dihydro-1H-indene

6-fluoro-5-isopropyl-2,3-dihydro-1H-inden-4-amine

Refernces

• 1、 Kikumoto,Tobe,Fukami,Egawa. "Synthesis and antianxiety activity of (ω-piperazinylalkoxy)indan derivatives". . p. 246 - 250. Retrieved 2007/10/02.