1α-Carboxymethyl-2α-methyl-2β-acetonyl-cyclohexan

Base Information

• Chemical Name: 1α-Carboxymethyl-2α-methyl-2β-acetonyl-cyclohexan
• CAS No.: 61195-37-7
• Molecular Formula: C₁₂H₂₀O₃
• Molecular Weight: 212.289
• Mol file: 61195-37-7.mol

Synonyms:

Chemical Property of 1α-Carboxymethyl-2α-methyl-2β-acetonyl-cyclohexan

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1α-Carboxymethyl-2α-methyl-2β-acetonyl-cyclohexan

There total 3 articles about 1α-Carboxymethyl-2α-methyl-2β-acetonyl-cyclohexan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,8aα-Dimethyl-5α-(1-methyl-2-hydroxy-propyloxy)-trans-Δ2-octalin (61195-20-8) → 1α-Carboxymethyl-2α-methyl-2β-acetonyl-cyclohexan (61195-37-7)

Guidance literature:

Multi-step reaction with 3 steps

1: CrO₃, H₂SO₄

2: N₂H₄*H₂O, KOH

3: (i) O₃, MeOH, (ii) H₂O₂, AcOH

With chromium(VI) oxide; potassium hydroxide; sulfuric acid; hydrazine hydrate;

DOI:10.1021/ja01021a045

Reference yield:

2,8aα-Dimethyl-trans-Δ2-octalin (61247-09-4) → 1α-Carboxymethyl-2α-methyl-2β-acetonyl-cyclohexan (61195-37-7)

Guidance literature:

Multistep reaction; (i) O₃, MeOH, (ii) H₂O₂, AcOH;

DOI:10.1021/ja01021a045

Reference yield:

2,8aα-Dimethyl-trans-Δ2-octalon-(5) (61247-08-3) → 1α-Carboxymethyl-2α-methyl-2β-acetonyl-cyclohexan (61195-37-7)

Guidance literature:

Multi-step reaction with 2 steps

1: N₂H₄*H₂O, KOH

2: (i) O₃, MeOH, (ii) H₂O₂, AcOH

With potassium hydroxide; hydrazine hydrate;

DOI:10.1021/ja01021a045

upstream raw materials:

2,8aα-Dimethyl-trans-Δ²-octalin

2,8aα-Dimethyl-trans-Δ²-octalon-(5)

2,8aα-Dimethyl-5α-(1-methyl-2-hydroxy-propyloxy)-trans-Δ²-octalin

Downstream raw materials:

((1S)-1-methyl-cyclohexane-1r,2t-diyl)-di-acetic acid