methyl 3-(3-(4-fluorophenyl)-5-thioxo-1H-1,2,4-triazol-4-ylimino)cholanate

Base Information

• Chemical Name: methyl 3-(3-(4-fluorophenyl)-5-thioxo-1H-1,2,4-triazol-4-ylimino)cholanate
• CAS No.: 1293362-45-4
• Molecular Formula: C₃₃H₄₅FN₄O₂S
• Molecular Weight: 580.81
• Mol file: 1293362-45-4.mol

Synonyms:

Chemical Property of methyl 3-(3-(4-fluorophenyl)-5-thioxo-1H-1,2,4-triazol-4-ylimino)cholanate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-(3-(4-fluorophenyl)-5-thioxo-1H-1,2,4-triazol-4-ylimino)cholanate

There total 6 articles about methyl 3-(3-(4-fluorophenyl)-5-thioxo-1H-1,2,4-triazol-4-ylimino)cholanate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-amino-5-(4-fluorophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione (61019-25-8) + methyl 3-oxo-5β-cholan-24-oate (1173-32-6) → methyl 3-(3-(4-fluorophenyl)-5-thioxo-1H-1,2,4-triazol-4-ylimino)cholanate (1293362-45-4)

Guidance literature:

With acetic acid; for 0.0666667h; Microwave irradiation;

DOI:10.3184/030823410X12892372673414

Reference yield:

4-Fluorobenzoic acid (456-22-4) → methyl 3-(3-(4-fluorophenyl)-5-thioxo-1H-1,2,4-triazol-4-ylimino)cholanate (1293362-45-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: thionyl chloride / Microwave irradiation

2.1: hydrazine hydrate / ethanol / Reflux

3.1: potassium hydroxide / ethanol / 20 °C

3.2: Reflux

4.1: acetic acid / 0.07 h / Microwave irradiation

With thionyl chloride; hydrazine hydrate; acetic acid; potassium hydroxide; In ethanol;

DOI:10.3184/030823410X12892372673414

Reference yield:

4-fluorobenzoyl hydrazide (456-06-4) → methyl 3-(3-(4-fluorophenyl)-5-thioxo-1H-1,2,4-triazol-4-ylimino)cholanate (1293362-45-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hydroxide / ethanol / 20 °C

1.2: Reflux

2.1: acetic acid / 0.07 h / Microwave irradiation

With acetic acid; potassium hydroxide; In ethanol;

DOI:10.3184/030823410X12892372673414

upstream raw materials:

4-amino-5-(4-fluorophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione

methyl 3-oxo-5β-cholan-24-oate

4-fluorobenzoic acid ethyl ester

4-Fluorobenzoic acid

Refernces