1β,4β,6β-trihydroxyeudesmane

Base Information

• Chemical Name: 1β,4β,6β-trihydroxyeudesmane
• CAS No.: 95457-15-1
• Molecular Formula: C₁₅H₂₈O₃
• Molecular Weight: 256.386
• Mol file: 95457-15-1.mol

Synonyms:

Chemical Property of 1β,4β,6β-trihydroxyeudesmane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1β,4β,6β-trihydroxyeudesmane

There total 2 articles about 1β,4β,6β-trihydroxyeudesmane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1β,4β-dihydroxy-6β-acetoxy-eudesmane (95457-12-8) → 1β,4β,6β-trihydroxyeudesmane (95457-15-1,227471-20-7)

Guidance literature:

With potassium hydroxide; In methanol; for 1h; Heating;

DOI:10.1016/S0031-9422(01)00340-5

Reference yield: 89.0%

6β-acetoxy-1β,4β-dihydroxyeudesmane (95457-12-8,105507-45-7,132586-88-0) → 1β,4β,6β-trihydroxyeudesmane (95457-15-1,105507-46-8,145400-17-5,227471-20-7)

Guidance literature:

With potassium hydroxide; In methanol; water; for 1h; Heating;

DOI:10.1016/S0040-4020(01)86290-6

Reference yield:

1β,4β,6β-trihydroxyeudesmane (95457-15-1,227471-20-7) → 1a,4b,6b-trihydroxyeudesmane (227471-20-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.54 g / Jones' reagent / acetone / 0 °C

2: 20 percent / Rhizopus nigricans CECT 2672 / ethanol / 144 h

With jones' reagent; Rhizopus nigricans CECT 2672; In ethanol; acetone;

DOI:10.1039/b301577g

upstream raw materials:

6β-acetoxy-1β,4β-dihydroxyeudesmane

1β,4β-dihydroxy-6β-acetoxy-eudesmane

Downstream raw materials:

1a,4b,6b-trihydroxyeudesmane

Refernces

• 1、 Garcia-Granados, Andres,Gutierrez, Maria C,Rivas, Francisco. "Improved microbiological hydroxylation of sesquiterpenoids: semisynthesis, structural determination and biotransformation studies of cyclic sulfite eudesmane derivatives.". . p. 2314 - 2320. Retrieved 2007/10/03.
• 2、 Garcia-Granados, Andres,Molina, Antonio,Buruaga, Antonio Saenz de,Buruaga, Juan Manuel Saenz de. "SESQUITERPENES FROM TWO SUBSPECIES OF SIDERITIS VAROI". . p. 97 - 102. Retrieved 2007/10/02.