N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-(2-sulfanylethyl)-beta-alaninamide

Base Information

• Chemical Name: N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-(2-sulfanylethyl)-beta-alaninamide
• CAS No.: 105974-69-4
• Molecular Formula: C₁₁H₂₃N₂O₇PS
• Molecular Weight: 358.353
• Mol file: 105974-69-4.mol

Synonyms:

Chemical Property of N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-(2-sulfanylethyl)-beta-alaninamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-(2-sulfanylethyl)-beta-alaninamide

There total 6 articles about N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-(2-sulfanylethyl)-beta-alaninamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

D-pantethine (138148-35-3,141630-68-4,16816-67-4,303-05-9) → D‐pantetheine 4'‐phosphate (2226-71-3,105974-69-4,13147-30-3,137044-41-8)

Guidance literature:

Multistep reaction; (i) ClPO(OCH₂Ph)2, benzene, (ii) aq. AcOH, (iii) Na, liq. NH₃;

DOI:10.1021/ja01464a036

Reference yield:

pantetheine (55512-69-1,84256-02-0,496-65-1) → D‐pantetheine 4'‐phosphate (2226-71-3,105974-69-4,13147-30-3,137044-41-8)

Guidance literature:

With pyruvate kinase; E_. coli coenzyme AA; ATP; magnesium chloride; In various solvent(s); at 20 ℃; pH=6.0; Kinetics;

DOI:10.1039/b512735a

Reference yield:

D-pantethine (138148-35-3,141630-68-4,16816-67-4,303-05-9) → D‐pantetheine 4'‐phosphate (2226-71-3,105974-69-4,13147-30-3,137044-41-8)

Guidance literature:

With pyridine; at -40 ℃; Behandeln des Reaktionsprodukts mit Natrium und fluessigem NH₃;

DOI:10.1039/jr9530001610

upstream raw materials:

D-pantethine

Cysteamine

pantetheine

(R)-Pantolacton

Downstream raw materials:

3′-dephospho-coenzyme A

Refernces

• 1、 Rath, Christopher M.,Benton, Bret M.,De Vicente, Javier,Drumm, Joseph E.,Geng, Mei,Li, Cindy,Moreau, Robert J.,Shen, Xiaoyu,Skepper, Colin K.,Steffek, Micah,Takeoka, Kenneth,Wang, Lisha,Wei, Jun-Rong,Xu, Wenjian,Zhang, Qiong,Feng, Brian Y.. "Optimization of CoaD Inhibitors against Gram-Negative Organisms through Targeted Metabolomics". . p. 391 - 402. Retrieved 2018.
• 2、 Worthington, Andrew S.,Burkart, Michael D.. "One-pot chemo-enzymatic synthesis of reporter-modified proteins". . p. 44 - 46. Retrieved 2007/10/03.