hydroxylysine

Base Information

• Chemical Name: hydroxylysine
• CAS No.: 78088-29-6
• Molecular Formula: C₆H₁₄N₂O₃
• Molecular Weight: 162.189
• Mol file: 78088-29-6.mol

Synonyms:

Chemical Property of hydroxylysine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of hydroxylysine

There total 45 articles about hydroxylysine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(2S,5R)-2,6-diazido-5-hydroxyhexanoic acid → (5R)-5-hydroxy-L-lysine (504-91-6,1190-94-9,3506-26-1,6000-08-4,18899-29-1,18899-30-4,18899-31-5,52153-41-0,78088-29-6,28902-93-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; at 20 ℃; for 15h; under 760.051 Torr;

DOI:10.1039/c4ob01220h

Reference yield:

L-lysine (56-87-1,3506-25-0) → (2S,5S)-5-hydroxylysine (18899-29-1,28902-93-4) + (5R)-5-hydroxy-L-lysine (504-91-6,1190-94-9,3506-26-1,6000-08-4,18899-29-1,18899-30-4,18899-31-5,52153-41-0,78088-29-6,28902-93-4) + (2S)-4-hydroxylysine (15574-69-3) + (2S)-2,6-diamino-3-hydroxyhexanoic acid

Guidance literature:

With oxygen; In water; γ-Irradiation;

DOI:10.1021/tx980118h

Reference yield:

type I collagen from Bester sturgeon scales → L-alanin (56-41-7,25191-17-7,18875-37-1) + L-valine (72-18-4,25609-85-2,7004-03-7,921-10-8) + L-serin (56-45-1,83245-15-2) + L-threonine (72-19-5,134357-96-3,7013-32-3,82822-12-6) + L-leucine (61-90-5,21675-61-6,25248-98-0,70-45-1) + L-isoleucine (73-32-5,959215-79-3,18875-42-8) + L-methionine (63-68-3,26062-47-5,58576-49-1) + L-lysine (56-87-1,3506-25-0) + L-Aspartic acid (56-84-8,25608-40-6,27881-03-4,32505-46-7,52526-39-3) + (5R)-5-hydroxy-L-lysine (504-91-6,1190-94-9,3506-26-1,6000-08-4,18899-29-1,18899-30-4,18899-31-5,52153-41-0,78088-29-6,28902-93-4) + L-arginine (74-79-3,25212-18-4) + S,S-cystine (349-46-2) + L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) + L-tyrosine (60-18-4,18875-48-4,25619-78-7,30704-25-7) + glycine (56-40-6,18875-39-3,25718-94-9) + L-proline (147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7) + 4R-4-hydroxyproline (51-35-4,30724-02-8) + L-histidine (71-00-1)

Guidance literature:

With hydrogenchloride; water; at 110 ℃; for 24h;

DOI:10.1016/j.foodchem.2014.03.075

upstream raw materials:

(2S,5R)-(-)-tert-butyl-6-amino-2-[(tert-butoxycarbonyl)amino]-5-hydroxyhexanoate

(R)-5-((S)-3-Amino-3-carboxy-propyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

(2S,5R)-6-azido-2-benzyloxycarbonylamino-5-hydroxyhexanoic acid

L-lysine

Downstream raw materials:

DL-threo-N²,N⁶-bis-(2,4-dinitro-phenyl)-5-hydroxy-lysine lactone

DL-threo-N²,N⁶-bis-(2,4-dinitro-phenyl)-5-hydroxy-lysine

(2S,5R)-5-hydroxy-2-piperidinecarboxylic acid

(2S,5R)-5-hydroxypiperidine-2-carboxylic acid

Refernces

• 1、 Guo, Lina,Liu, Taibao,Chen, Kai,Song, Tianbang,Wang, Peng George,Zhao, Wei. "Facile synthesis of 5-hydroxy-l-lysine from d-galactose as a chiral-precursor". . p. 7310 - 7317. Retrieved 2014/11/07.
• 2、 Allevi, Pietro,Anastasia, Mario. "Synthesis of all four possible stereoisomers of 5-hydroxylysine". . p. 3151 - 3160. Retrieved 2007/10/03.