2-amyl-2-ethyl-malonic acid diethyl ester

Base Information

• Chemical Name: 2-amyl-2-ethyl-malonic acid diethyl ester
• CAS No.: 5408-35-5
• Molecular Formula: C14H26 O4
• Molecular Weight: 258.358
• Hs Code.: 2917190090
• Mol file: 5408-35-5.mol

Synonyms:Malonicacid, ethylpentyl-, diethyl ester (8CI); Propanedioic acid, ethylpentyl-,diethyl ester (9CI); NSC 10823; NSC 128052

Chemical Property of 2-amyl-2-ethyl-malonic acid diethyl ester

Chemical Property:

• Vapor Pressure: 0.00461mmHg at 25°C
• Boiling Point: 277.1°C at 760 mmHg
• Flash Point: 120.1°C
• PSA: 52.60000
• Density: 0.968g/cm³
• LogP: 3.08930

Purity/Quality:

99%min ^*data from raw suppliers

DIETHYL ETHYL-N-AMYLMALONATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-amyl-2-ethyl-malonic acid diethyl ester

There total 6 articles about 2-amyl-2-ethyl-malonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

ethyl bromide (74-96-4) + diethyl n-pentylmalonate (6065-59-4) → ethyl-pentyl-malonic acid diethyl ester (5408-35-5)

Guidance literature:

With calcium oxide; In N,N-dimethyl-formamide; at 80 - 85 ℃; for 7h;

Reference yield: 36.0%

1-Bromopentane (110-53-2) + ethyl diethyl malonate (133-13-1) → ethyl-pentyl-malonic acid diethyl ester (5408-35-5)

Guidance literature:

With calcium oxide; In N,N-dimethyl-formamide; at 80 - 85 ℃; for 6.5h;

Reference yield:

diethyl malonate (105-53-3) → ethyl-pentyl-malonic acid diethyl ester (5408-35-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / potassium carbonate / triethylbenzylammonium chloride / dimethylformamide / 4 h / 60 °C / other solvent, other temperature, other reaction time

2: 36 percent / CaO / dimethylformamide / 6.5 h / 80 - 85 °C

With potassium carbonate; calcium oxide; N-benzyl-N,N,N-triethylammonium chloride; In N,N-dimethyl-formamide;

upstream raw materials:

1-Bromopentane

ethyl diethyl malonate

ethyl bromide

diethyl n-pentylmalonate

Downstream raw materials:

5-ethyl-1-methyl-5-pentyl-barbituric acid

2-ethylheptanoic acid

Refernces