Technology Process of 7-methylheptalactone
There total 1 articles about 7-methylheptalactone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
cycloheptanone;
With
lithium diisopropyl amide;
In
tetrahydrofuran; hexane;
at 0 ℃;
for 0.5h;
methyl iodide;
In
tetrahydrofuran; hexane;
at -78 ℃;
With
3-chloro-benzenecarboperoxoic acid;
In
chloroform;
for 168000h;
Further stages. Title compound not separated from byproducts.;
DOI:10.1021/ja071241a
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: porcine liver esteraze; NaOH / aq. phosphate buffer / pH 7.2
2.1: carbonyl diimidazole / tetrahydrofuran / 4 h / 0 °C
2.2: 74 percent / tetrahydrofuran / cooling
3.1: 99 percent / [((R)-BINAP)RuCl2]2*NEt3; H2 / methanol; tetrahydrofuran / 15 h / 65 °C / 15001.5 Torr
4.1: molecular sieves 4 Angstroem / CH2Cl2 / 0.5 h / 20 °C
4.2: 82 percent / TMSOTf / CH2Cl2 / 2.5 h / -78 °C
5.1: 82 percent / LiAlH4 / tetrahydrofuran / 1 h / 0 °C
6.1: tri-n-butylphosphine; o-nitrophenyl selenocyanate / tetrahydrofuran / 30 h
6.2: 90 percent / aq. H2O2 / tetrahydrofuran / 0 - 20 °C
With
sodium hydroxide; lithium aluminium tetrahydride; ortho-nitrophenyl selenocyanate; tributylphosphine; [((R)-Binap)-RuCl2]2; 4 A molecular sieve; porcine liver esteraze; hydrogen; 1,1'-carbonyldiimidazole;
In
tetrahydrofuran; methanol; phosphate buffer; dichloromethane;
DOI:10.1021/ja027346p
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: porcine liver esteraze; NaOH / aq. phosphate buffer / pH 7.2
2.1: carbonyl diimidazole / tetrahydrofuran / 4 h / 0 °C
2.2: 74 percent / tetrahydrofuran / cooling
3.1: 99 percent / [((R)-BINAP)RuCl2]2*NEt3; H2 / methanol; tetrahydrofuran / 15 h / 65 °C / 15001.5 Torr
4.1: molecular sieves 4 Angstroem / CH2Cl2 / 0.5 h / 20 °C
4.2: 82 percent / TMSOTf / CH2Cl2 / 2.5 h / -78 °C
With
sodium hydroxide; [((R)-Binap)-RuCl2]2; 4 A molecular sieve; porcine liver esteraze; hydrogen; 1,1'-carbonyldiimidazole;
In
tetrahydrofuran; methanol; phosphate buffer; dichloromethane;
DOI:10.1021/ja027346p
