2-<(acetylamino)methyl>-1,4-dibenzylpiperazine

Base Information

• Chemical Name: 2-<(acetylamino)methyl>-1,4-dibenzylpiperazine
• CAS No.: 124257-72-3
• Molecular Formula: C₂₁H₂₇N₃O
• Molecular Weight: 337.465
• Mol file: 124257-72-3.mol

Synonyms:

Chemical Property of 2-<(acetylamino)methyl>-1,4-dibenzylpiperazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-<(acetylamino)methyl>-1,4-dibenzylpiperazine

There total 2 articles about 2-<(acetylamino)methyl>-1,4-dibenzylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

acetic anhydride (108-24-7) + 1,4-dibenzyl-2-piperazinecarbonitrile (170701-81-2) → 2-<(acetylamino)methyl>-1,4-dibenzylpiperazine (124257-72-3)

Guidance literature:

With hydrogen; nickel; Ambient temperature;

DOI:10.1248/cpb.43.1137

Reference yield:

acetic anhydride (108-24-7) + 2-chloromethyl-1,4-bis(phenylmethyl)piperazine (24225-89-6) → 6-(acetylamino)-1,4-dibenzylhexahydro-1H-1,4-diazepine (124257-73-4) + 2-<(acetylamino)methyl>-1,4-dibenzylpiperazine (124257-72-3)

Guidance literature:

With sodium azide; sodium bis(2-methoxyethoxy)aluminium dihydride; Yield given. Multistep reaction. Yields of byproduct given;

DOI:10.1248/cpb.43.1364

Reference yield:

2-<(acetylamino)methyl>-1,4-dibenzylpiperazine (124257-72-3) → 4-Amino-5-chloro-N-(1,4-dibenzyl-piperazin-2-ylmethyl)-2-methoxy-benzamide

Guidance literature:

Multi-step reaction with 2 steps

1: 10percent aq. HCl

2: 75 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH₂Cl₂ / 5 h / Ambient temperature

With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;

DOI:10.1248/cpb.43.1364

upstream raw materials:

acetic anhydride

2-chloromethyl-1,4-bis(phenylmethyl)piperazine

1,4-dibenzyl-2-piperazinecarbonitrile

Downstream raw materials:

2-aminomethyl-1,4-di-phenylmethyl piperazine

Refernces

• 1、 Morie,Kato,Harada,Yoshida,Fujiwara,Matsumoto. "Synthesis and structure-activity relationships of 4-amino-5-chloro-2- ethoxybenzamides with six- and seven-membered heteroalicycles as potential gastroprokinetic agents". . p. 1137 - 1147. Retrieved 2007/10/02.