2-{[(3-CHLOROPHENYL)AMINO]CARBONYL}-BENZOIC ACID

Base Information

• Chemical Name: 2-{[(3-CHLOROPHENYL)AMINO]CARBONYL}-BENZOIC ACID
• CAS No.: 5406-21-3
• Molecular Formula: C14H10 Cl N O3
• Molecular Weight: 275.691
• Hs Code.: 2924299090
• Mol file: 5406-21-3.mol

Synonyms:Phthalanilicacid, 3'-chloro- (6CI,7CI,8CI); 2-[(3-Chlorophenyl)aminocarbonyl]benzoic acid;NSC 406172; NSC 6963

Chemical Property of 2-{[(3-CHLOROPHENYL)AMINO]CARBONYL}-BENZOIC ACID

Chemical Property:

• Vapor Pressure: 1.48E-06mmHg at 25°C
• Boiling Point: 383.2°Cat760mmHg
• Flash Point: 185.5°C
• PSA: 66.40000
• Density: 1.43g/cm³
• LogP: 3.36350

Purity/Quality:

99% ^*data from raw suppliers

N-(3-Chloro-phenyl)-phthalamic acid 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-{[(3-CHLOROPHENYL)AMINO]CARBONYL}-BENZOIC ACID

There total 2 articles about 2-{[(3-CHLOROPHENYL)AMINO]CARBONYL}-BENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

phthalic anhydride (85-44-9) + 3-chloro-aniline (108-42-9) → 2-[(3-chlorophenyl)aminocarbonyl]benzoic acid (5406-21-3)

Guidance literature:

at 135 ℃; for 0.0333333h; microwave irradiation;

DOI:10.1016/S0960-894X(01)00540-6

Reference yield:

→ 2-[(3-chlorophenyl)aminocarbonyl]benzoic acid (5406-21-3)

Guidance literature:

Phtalsaeureanhydrid, 3-Chloranilin, Bzl., Siedetemp.;

Reference yield: 58.0%

2-[(3-chlorophenyl)aminocarbonyl]benzoic acid (5406-21-3) → N-(3-chlorophenyl)phthalimide (16082-71-6)

Guidance literature:

With acetic acid; at 80 ℃; for 2h;

DOI:10.1039/b008399m

upstream raw materials:

phthalic anhydride

3-chloro-aniline

Downstream raw materials:

N-(3-chlorophenyl)phthalimide

Refernces

• 1、 Perry, Christopher J.,Parveen, Zahida. "The cyclisation of substituted phthalanilic acids in acetic acid solution. A kinetic study of substituted N-phenylphthalimide formation". . p. 512 - 521. Retrieved 2007/10/03.