Technology Process of Meptazinol iMpurity E
There total 5 articles about Meptazinol iMpurity E which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 20 ℃;
for 6h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran; hexane / 2.33 h / 0 °C
2.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran; hexane / 1.25 h / 0 °C
2.2: 15.5 h / 20 °C / Cooling with ice
3.1: boron tribromide / dichloromethane / 3.5 h / 0 °C
4.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 40 °C
5.1: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / 20 °C / Reflux
With
2,2,6,6-tetramethyl-piperidine; lithium aluminium tetrahydride; n-butyllithium; boron tribromide; potassium carbonate;
In
tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran; hexane / 2.33 h / 0 °C
2.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran; hexane / 1.25 h / 0 °C
2.2: 15.5 h / 20 °C / Cooling with ice
3.1: boron tribromide / dichloromethane / 3.5 h / 0 °C
4.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 40 °C
5.1: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / 20 °C / Reflux
With
2,2,6,6-tetramethyl-piperidine; lithium aluminium tetrahydride; n-butyllithium; boron tribromide; potassium carbonate;
In
tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;