C₂₆H₃₁FN₃O₁₀P

Base Information

• Chemical Name: C₂₆H₃₁FN₃O₁₀P
• CAS No.: 1613589-28-8
• Molecular Formula: C₂₆H₃₁FN₃O₁₀P
• Molecular Weight: 595.518
• Mol file: 1613589-28-8.mol

Synonyms:

Chemical Property of C₂₆H₃₁FN₃O₁₀P

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₆H₃₁FN₃O₁₀P

There total 12 articles about C₂₆H₃₁FN₃O₁₀P which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5'-deoxyuridin-4'-ene (14365-63-0) → C26H31FN3O10P (1613589-28-8)

Guidance literature:

Multi-step reaction with 8 steps

1.1: triethylamine tris(hydrogen fluoride); N-iodo-succinimide / acetonitrile / 1 h / 0 - 20 °C

2.1: dmap; pyridine / 16 h / 50 °C

3.1: 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; tetra(n-butyl)ammonium hydroxide / dichloromethane; water / pH Ca_. 4

4.1: ammonia / methanol / 5 h

5.1: pyridine / 12 h / 0 - 20 °C

6.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / acetonitrile / 3 h / 80 °C

7.1: tetrahydrofuran; cyclohexane / 1 h / 20 °C

7.2: 0.5 h

8.1: 1-methyl-1H-imidazole / acetonitrile / 40 °C

With pyridine; 1-methyl-1H-imidazole; dmap; N-iodo-succinimide; tetra(n-butyl)ammonium hydroxide; ammonia; triethylamine tris(hydrogen fluoride); 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; methanol; dichloromethane; cyclohexane; water; acetonitrile;

Reference yield:

5'-deoxy-5'-iodo-4'-fluoro-2',3'-di-O-benzoyluridine (1613589-22-2) → C26H31FN3O10P (1613589-28-8)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; tetra(n-butyl)ammonium hydroxide / dichloromethane; water / pH Ca_. 4

2.1: ammonia / methanol / 5 h

3.1: pyridine / 12 h / 0 - 20 °C

4.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / acetonitrile / 3 h / 80 °C

5.1: tetrahydrofuran; cyclohexane / 1 h / 20 °C

5.2: 0.5 h

6.1: 1-methyl-1H-imidazole / acetonitrile / 40 °C

With pyridine; 1-methyl-1H-imidazole; tetra(n-butyl)ammonium hydroxide; ammonia; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; methanol; dichloromethane; cyclohexane; water; acetonitrile;

Reference yield:

4'-fluoro-2',3'-di-O-benzoyluridine (1613589-23-3) → C26H31FN3O10P (1613589-28-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: ammonia / methanol / 5 h

2.1: pyridine / 12 h / 0 - 20 °C

3.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / acetonitrile / 3 h / 80 °C

4.1: tetrahydrofuran; cyclohexane / 1 h / 20 °C

4.2: 0.5 h

5.1: 1-methyl-1H-imidazole / acetonitrile / 40 °C

With pyridine; 1-methyl-1H-imidazole; ammonia; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; methanol; cyclohexane; acetonitrile;

upstream raw materials:

uridine

1-((2R,3R,4S,5S)-3,4-dihydroxy-5-iodomethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione

5′-deoxy-5′-iodo-4′-fluorouridine

5'-deoxyuridin-4'-ene

Refernces

• 1、 -. "SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF". . . Retrieved 2015/04/21.
• 2、 -. "SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF". . . Retrieved 2016/03/08.