2-AMino-4-broMo-5-Methoxy-benzoic acid

Base Information

• Chemical Name: 2-AMino-4-broMo-5-Methoxy-benzoic acid
• CAS No.: 1623120-79-5
• Molecular Formula: C₈H₈BrNO₃
• Molecular Weight: 246.06
• Mol file: 1623120-79-5.mol

Synonyms:

Chemical Property of 2-AMino-4-broMo-5-Methoxy-benzoic acid

Chemical Property:

• Boiling Point: 381.7±42.0 °C(Predicted)
• PKA: 4.59±0.10(Predicted)
• Density: 1.703±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-4-bromo-5-methoxybenzoicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-AMino-4-broMo-5-Methoxy-benzoic acid

There total 7 articles about 2-AMino-4-broMo-5-Methoxy-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.88%

methyl 2-amino-4-bromo-5-methoxybenzoate (1256955-36-8) → 2-amino-4-bromo-5-methoxybenzoic acid (1623120-79-5)

Guidance literature:

With methanol; lithium hydroxide monohydrate; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield: 68.0%

4-bromo-5-methoxy-2-nitrobenzoic acid (1527490-64-7) → 2-amino-4-bromo-5-methoxybenzoic acid (1623120-79-5)

Guidance literature:

With iron; acetic acid; In ethanol; at 70 ℃; for 18h;

Reference yield: 51.0%

methanol (67-56-1) + 3-bromo-4-fluoro-6-methylnitrobenzene (224185-19-7) → 2-amino-4-bromo-5-methoxybenzoic acid (1623120-79-5)

Guidance literature:

With selenium; nitrobenzene; sodium hydroxide; In water; dimethyl sulfoxide; at 90 ℃; for 5h; Inert atmosphere;

DOI:10.1039/d0gc04407e

upstream raw materials:

methyl 2-amino-4-bromo-5-methoxybenzoate

4-bromo-3-fluorobenzoic acid

4-bromo-5-fluoro-2-nitrobenzoic acid

methyl 4-bromo-5-fluoro-2-nitrobenzoate

Downstream raw materials:

4-chloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-6-methoxy-3-nitroquinoline

Refernces

• 1、 -. "BICYCLIC HETEROCYCLE COMPOUNDS METHODS OF USE THEREOF FOR THE TREATMENT OF HERPES VIRUSES". Page/Page column 37. . Retrieved 2021/06/26.
• 2、 -. "Spiro-substituted pyrimido-cyclic compound, and preparation method and medical application thereof". . . Retrieved 2020/12/31.