(Z)-1-(4-hydroxyphenyl)-2-(4-isopropylphenyl)-1-<4-<2-(methylamino)ethoxy>phenyl>-1-butene hydrochloride

Base Information

• Chemical Name: (Z)-1-(4-hydroxyphenyl)-2-(4-isopropylphenyl)-1-<4-<2-(methylamino)ethoxy>phenyl>-1-butene hydrochloride
• CAS No.: 135247-72-2
• Molecular Formula: C₂₈H₃₃NO₂*ClH
• Molecular Weight: 452.036
• Mol file: 135247-72-2.mol

Synonyms:

Chemical Property of (Z)-1-(4-hydroxyphenyl)-2-(4-isopropylphenyl)-1-<4-<2-(methylamino)ethoxy>phenyl>-1-butene hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-1-(4-hydroxyphenyl)-2-(4-isopropylphenyl)-1-<4-<2-(methylamino)ethoxy>phenyl>-1-butene hydrochloride

There total 7 articles about (Z)-1-(4-hydroxyphenyl)-2-(4-isopropylphenyl)-1-<4-<2-(methylamino)ethoxy>phenyl>-1-butene hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4-isopropylphenyl)acetonitrile (4395-87-3) → (Z)-1-(4-hydroxyphenyl)-2-(4-isopropylphenyl)-1-<4-<2-(methylamino)ethoxy>phenyl>-1-butene hydrochloride (135247-72-2)

Guidance literature:

Multi-step reaction with 7 steps

1: 78.7 percent / 50percent aq. NaOH, triethylbenzylammonium chloride (TEBAC)

2: 85.6 percent / 70percent H₂SO₄ / 3 h / 150 °C

3: SOCl₂

4: 82.2 percent / AlCl₃ / CH₂Cl₂ / 3 h / Ambient temperature

5: 75.2 percent / pyridine hydrochloride / 2 h / 230 °C

6: 1.) NaH / 1.) DMF, RT, 2 h, 2.) 100 deg C, 2h

With sodium hydroxide; aluminium trichloride; thionyl chloride; sulfuric acid; N-benzyl-N,N,N-triethylammonium chloride; pyridine hydrochloride; sodium hydride; In dichloromethane;

DOI:10.1248/cpb.39.911

Reference yield:

2-(4-isopropylphenyl)butyronitrile (124284-57-7) → (Z)-1-(4-hydroxyphenyl)-2-(4-isopropylphenyl)-1-<4-<2-(methylamino)ethoxy>phenyl>-1-butene hydrochloride (135247-72-2)

Guidance literature:

Multi-step reaction with 6 steps

1: 85.6 percent / 70percent H₂SO₄ / 3 h / 150 °C

2: SOCl₂

3: 82.2 percent / AlCl₃ / CH₂Cl₂ / 3 h / Ambient temperature

4: 75.2 percent / pyridine hydrochloride / 2 h / 230 °C

5: 1.) NaH / 1.) DMF, RT, 2 h, 2.) 100 deg C, 2h

With aluminium trichloride; thionyl chloride; sulfuric acid; pyridine hydrochloride; sodium hydride; In dichloromethane;

DOI:10.1248/cpb.39.911

Reference yield:

2-(4-Isopropyl-phenyl)-butyryl chloride → (Z)-1-(4-hydroxyphenyl)-2-(4-isopropylphenyl)-1-<4-<2-(methylamino)ethoxy>phenyl>-1-butene hydrochloride (135247-72-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 82.2 percent / AlCl₃ / CH₂Cl₂ / 3 h / Ambient temperature

2: 75.2 percent / pyridine hydrochloride / 2 h / 230 °C

3: 1.) NaH / 1.) DMF, RT, 2 h, 2.) 100 deg C, 2h

With aluminium trichloride; pyridine hydrochloride; sodium hydride; In dichloromethane;

DOI:10.1248/cpb.39.911

upstream raw materials:

4-(tetrahydropyran-2'-yloxy)-1-bromobenzene

1-<4-<2-(dimethylamino)ethoxy>phenyl>-2-(4-isopropylphenyl)-1-butanone

(4-isopropylphenyl)acetonitrile

2-(4-isopropylphenyl)butyronitrile

Refernces