hystazarin

Base Information

• Chemical Name: hystazarin
• CAS No.: 483-35-2
• Molecular Formula: C14H8 O4
• Molecular Weight: 240.215
• Mol file: 483-35-2.mol

Synonyms:Anthraquinone,2,3-dihydroxy- (8CI); Hystazarin (6CI); 2,3-Dihydroxy-9,10-anthraquinone;2,3-Dihydroxyanthraquinone; Hystazin

Chemical Property of hystazarin

Chemical Property:

• Melting Point: 260-262 °C
• Boiling Point: 424.9±40.0 °C(Predicted)
• PKA: 6.95±0.20(Predicted)
• PSA: 74.60000
• Density: 1.540±0.06 g/cm3(Predicted)
• LogP: 1.87320

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of hystazarin

There total 6 articles about hystazarin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

2,3-bis(trimethylsilyloxy)-1,3-butadiene (31411-71-9) + [1,4]naphthoquinone (130-15-4) → 2-hydroxy-9,10-anthraquinone (605-32-3) + hystazarin (483-35-2)

Guidance literature:

In toluene; for 24h; Yields of byproduct given; Heating;

DOI:10.1016/S0040-4020(97)00297-4

Reference yield: 15.0%

phthalic anhydride (85-44-9) + benzene-1,2-diol (120-80-9,19481-10-8,37349-32-9) → hystazarin (483-35-2)

Guidance literature:

phthalic anhydride; benzene-1,2-diol; With aluminum (III) chloride; sodium chloride; at 110 - 165 ℃; for 4h;

With hydrogenchloride; In water; at 20 - 100 ℃; for 0.75h;

DOI:10.1021/jm301504b

Reference yield:

phthalic anhydride (85-44-9) + benzene-1,2-diol (120-80-9,19481-10-8,37349-32-9) → hystazarin (483-35-2) + 1,2-dihydroxy-9,10-anthracenedione (72-48-0,84754-86-9)

Guidance literature:

With Japanese acid earth;

DOI:10.1246/bcsj.3.289

upstream raw materials:

phthalic anhydride

benzo-1,4-dioxane

benzene-1,2-diol

2-(3,4-dimethoxybenzoyl)benzoic acid

Downstream raw materials:

2,3-dimethoxy-anthraquinone

1,4-diamino-2,3-dihydroxy-anthraquinone

2,3-bis-n-decyloxyanthracene

1,2-dihydroxy-9,10-anthracenedione

Refernces

• 1、 Zhang, Zhichao,Li, Xiangqian,Song, Ting,Zhao, Yan,Feng, Yingang. "An anthraquinone scaffold for putative, two-face bim BH3 α-helix mimic". . p. 10735 - 10741. Retrieved 2013/02/23.
• 2、 Danielsen,Francis,Aksnes. "1H and 13C NMR studies of some anthraquinones and anthracenetetrones". . p. 1043 - 1045. Retrieved 2007/10/03.