4-(5-BROMO-2-THIENYL)-4-OXOBUTYRIC ACID

Base Information

• Chemical Name: 4-(5-BROMO-2-THIENYL)-4-OXOBUTYRIC ACID
• CAS No.: 52240-28-5
• Molecular Formula: C₈H₇BrO₃S
• Molecular Weight: 263.112
• Mol file: 52240-28-5.mol

Synonyms:

Chemical Property of 4-(5-BROMO-2-THIENYL)-4-OXOBUTYRIC ACID

Chemical Property:

• Melting Point: 136-138°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

4-(5-Bromo-2-thienyl)-4-oxobutyricacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(5-BROMO-2-THIENYL)-4-OXOBUTYRIC ACID

There total 6 articles about 4-(5-BROMO-2-THIENYL)-4-OXOBUTYRIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-bromothiophene (1003-09-4) + succinic acid anhydride (108-30-5) → 4-(5-bromothien-2-yl)-4-oxobutanoic acid (52240-28-5)

Guidance literature:

With aluminium trichloride; In nitrobenzene; at -5 - 20 ℃;

DOI:10.1021/jo015644j

Reference yield: 56.0%

2-bromothiophene (1003-09-4) + succinic acid anhydride (108-30-5) → 1-[3-(5-bromo-2-thenoyl)propionyl]-L-proline (80885-88-7) + 4-(5-bromothien-2-yl)-4-oxobutanoic acid (52240-28-5)

Guidance literature:

Reference yield: 7.8%

2-bromothiophene (1003-09-4) + succinoyl dichloride (543-20-4) → 4-(5-bromothien-2-yl)-4-oxobutanoic acid (52240-28-5) + 4,4-bis(5-bromo-2-thienyl)-3-butenoic Acid (1289489-53-7) + C12H8Br2O2S2 (1289489-58-2)

Guidance literature:

With titanium tetrachloride; In dichloromethane; at 40 ℃; for 12h;

DOI:10.1007/s10593-011-0653-z

upstream raw materials:

2-bromothiophene

succinic acid anhydride

succinoyl dichloride

Downstream raw materials:

2-bromo-3,5-dinitro-thiophene

4-(5-bromo-4-nitro-thiophen-2-yl)-4-oxo-butyric acid

Refernces

• 1、 Seed, Alexander J.,Sonpatki, Vaishali,Herbert, Mark R.,Ono, Ayako,Narasaka, Koichi. "3-(4-Bromobenzoyl)propanoic acid [ bromobutanoic acid, 4-bromo-?-oxo- ]". . p. 204 - 204. Retrieved 2017/09/08.
• 2、 -. "OMEGA-HETEROAROYL(PROPIONYL OR BUTYRYL)-L-PROLINES". . . Retrieved 2008/06/13.