butyl 3-bromo-4-hydroxybenzoate

Base Information

• Chemical Name: butyl 3-bromo-4-hydroxybenzoate
• CAS No.: 37470-61-4
• Molecular Formula: C₁₁H₁₃BrO₃
• Molecular Weight: 273.126
• Mol file: 37470-61-4.mol

Synonyms:

Chemical Property of butyl 3-bromo-4-hydroxybenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of butyl 3-bromo-4-hydroxybenzoate

There total 3 articles about butyl 3-bromo-4-hydroxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

di(methyl)tert-butyl(n-butoxy)silane (37170-50-6) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → butyl 3-bromo-4-hydroxybenzoate (37470-61-4)

Guidance literature:

With Bromotrichloromethane; [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; In acetonitrile; at 20 ℃; for 7h; Reagent/catalyst; Solvent; Catalytic behavior; Irradiation; Inert atmosphere;

DOI:10.1055/s-0037-1610717

Reference yield:

3-bromo-4-hydroxy-benzoic acid (14348-41-5) + butan-1-ol (71-36-3) → butyl 3-bromo-4-hydroxybenzoate (37470-61-4)

Guidance literature:

With sulfuric acid; Reflux;

DOI:10.1021/acsmedchemlett.7b00431

Reference yield:

4-hydroxybenzoic acid, butyl ester (94-26-8) → butyl 3-bromo-4-hydroxybenzoate (37470-61-4)

Guidance literature:

With chloroform; bromine;

upstream raw materials:

4-hydroxybenzoic acid, butyl ester

3-bromo-4-hydroxy-benzoic acid

butan-1-ol

di(methyl)tert-butyl(n-butoxy)silane

Refernces

• 1、 Bergquist, Bridget L.,Jefferson, Kaelyn G.,Kintz, Hailey N.,Barber, Amorette E.,Yeagley, Andrew A.. "Disconnecting the Estrogen Receptor Binding Properties and Antimicrobial Properties of Parabens through 3,5-Substitution". supporting information. p. 51 - 55. Retrieved 2018/05/04.