alpha-Phenylbenzenepentanoic acid

Base Information

• Chemical Name: alpha-Phenylbenzenepentanoic acid
• CAS No.: 22055-24-9
• Molecular Formula: C₁₇H₁₈O₂
• Molecular Weight: 254.329
• DSSTox Substance ID: DTXSID701307256
• Wikidata: Q69757136
• Mol file: 22055-24-9.mol

Synonyms:alpha-Phenylbenzenepentanoic acid;SCHEMBL10869186;DTXSID701307256;AKOS004905996;22055-24-9

Chemical Property of alpha-Phenylbenzenepentanoic acid

Chemical Property:

• XLogP3: 4.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 6
• Exact Mass: 254.130679813
• Heavy Atom Count: 19
• Complexity: 262

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CCCC(C2=CC=CC=C2)C(=O)O

Technology Process of alpha-Phenylbenzenepentanoic acid

There total 9 articles about alpha-Phenylbenzenepentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2,5-diphenylpentanonitrile (6443-81-8) → 2,5-diphenylvaleric acid (22055-24-9,104122-59-0,104122-60-3)

Guidance literature:

With sulfuric acid; water; In acetic acid; for 7h; Heating;

DOI:10.1248/cpb.36.2386

Reference yield:

1-Bromo-3-phenylpropane (637-59-2) → 2,5-diphenylvaleric acid (22055-24-9,104122-59-0,104122-60-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF, 30 min, room temp; 2.) toluene 4 h

2: 91 percent / H₂O, H₂SO₄ / acetic acid / 7 h / Heating

With sulfuric acid; water; sodium hydride; In acetic acid;

DOI:10.1248/cpb.36.2386

Reference yield:

phenylacetonitrile (140-29-4) → 2,5-diphenylvaleric acid (22055-24-9,104122-59-0,104122-60-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF, 30 min, room temp; 2.) toluene 4 h

2: 91 percent / H₂O, H₂SO₄ / acetic acid / 7 h / Heating

With sulfuric acid; water; sodium hydride; In acetic acid;

DOI:10.1248/cpb.36.2386

upstream raw materials:

2,5-diphenylpentanonitrile

4-hydroxy-2,5-diphenyl-valeric acid

ethanol

5-benzylidene-3-phenyl-5H-furan-2-one

Downstream raw materials:

N-(1-phenyl-2-butyl)-2,5-diphenylvaleramide

2,5-Diphenyl-pentanoic acid [1-(4-methoxy-benzyl)-propyl]-amide

2-phenyl-1-benzosuberone

2,5-diphenylpentanol

Refernces