Technology Process of (S)-4-((4-(6-chloropyridin-3-yl)-6-(3-methylmorpholino)-1,3,5-triazin-2-yl)oxy)-3-fluoro-N,N-dimethylbenzamide
There total 4 articles about (S)-4-((4-(6-chloropyridin-3-yl)-6-(3-methylmorpholino)-1,3,5-triazin-2-yl)oxy)-3-fluoro-N,N-dimethylbenzamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium tert-butylate / dichloromethane; isopropyl alcohol / 0 °C
2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 4 h / 0 °C
4: potassium carbonate; 18-crown-6 ether / tetrahydrofuran / 2 h / 60 °C
With
lithium aluminium tetrahydride; 18-crown-6 ether; potassium tert-butylate; potassium carbonate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; dichloromethane; isopropyl alcohol;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 4 h / 0 °C
3: potassium carbonate; 18-crown-6 ether / tetrahydrofuran / 2 h / 60 °C
With
lithium aluminium tetrahydride; 18-crown-6 ether; potassium carbonate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / tetrahydrofuran / 20 °C / Inert atmosphere
2.1: trichlorophosphate / 0.25 h / 120 °C / Sealed tube
2.2: 12 h / 20 °C
3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 4 h / 0 °C
4.1: potassium carbonate; 18-crown-6 ether / tetrahydrofuran / 2 h / 60 °C
With
4-methyl-morpholine; 18-crown-6 ether; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trichlorophosphate;
In
tetrahydrofuran;