Magnoflorine iodide

Base Information

• Chemical Name: Magnoflorine iodide
• CAS No.: 4277-43-4
• Molecular Formula: C₂₀H₂₄NO₄*I
• Molecular Weight: 469.319
• NSC Number: 150447
• DSSTox Substance ID: DTXSID00195420
• Metabolomics Workbench ID: 139033
• ChEMBL ID: CHEMBL494052
• Mol file: 4277-43-4.mol

Synonyms:MAGNOFLORINE IODIDE;4277-43-4;Corytuberine Methiodide;Magnoflorine, iodide;(+)-Magnoflorine (iodide);NSC 150447;Thalictrine Iodide;(6aS)-2,10-dimethoxy-6,6-dimethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-6-ium-1,11-diol;iodide;4H-Dibenzo(de,g)quinolinium, 5,6,6a,7-tetrahydro-1,11-dihydroxy-2,10-dimethoxy-6,6-dimethyl-, iodide, (S)-;(+)-Magnoflorine Iodide;(+)-MAGNOFLORINEIODIDE;Oc1c(OC)cc2CCN(C)(C)C3Cc4ccc(OC)c(O)c4c1c23;C20H24NO4.I;Magnoflorine-iodide;CHEMBL494052;HY-N0334A;DTXSID00195420;C20-H24-N-O4.I;MFCD03427294;NSC150447;Magnoflorine;-Magnoflorine;Thalictrine;AKOS025401511;NSC-150447;AC-20269;AC-34487;MS-28671;CS-0018633;F17667

Chemical Property of Magnoflorine iodide

Chemical Property:

• Melting Point: 248-249oC
• PSA: 58.92000
• LogP: -0.02550
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 469.07501
• Heavy Atom Count: 26
• Complexity: 498

Purity/Quality:

95%-98% ^*data from raw suppliers

Magnoflorine Iodide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[N+]1(CCC2=CC(=C(C3=C2C1CC4=C3C(=C(C=C4)OC)O)O)OC)C.[I-]
• Isomeric SMILES: C[N+]1(CCC2=CC(=C(C3=C2[C@@H]1CC4=C3C(=C(C=C4)OC)O)O)OC)C.[I-]
• Uses: A minor alkaloid from Stylophorum diphyllum as antimicrobial and antitumor A minor alkaloid from Stylophorum diphyllum as antimicrobial and antitumor agent.

Technology Process of Magnoflorine iodide

There total 3 articles about Magnoflorine iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

corytuberine (517-56-6,71630-07-4) + methyl iodide (74-88-4) → (+)-magnoflorine iodide (4277-43-4)

Guidance literature:

In methanol; for 336h; Ambient temperature;

Reference yield:

magnoflorine chloride (6681-18-1) → (+)-magnoflorine iodide (4277-43-4)

Guidance literature:

With hydrogen iodide; potassium iodide; In methanol; Yield given;

DOI:10.1002/ardp.19813140311

Reference yield:

methyl iodide (74-88-4) → (+)-magnoflorine iodide (4277-43-4)

Guidance literature:

With methanol;

DOI:10.1248/cpb1953.2.329 DOI:10.1007/BF00925229

upstream raw materials:

magnoflorine chloride

corytuberine

methyl iodide

Downstream raw materials:

O,O'-Dimethyl-magnoflorin-iodid

Refernces

• 1、 Lu, Sheng-Teh,Tsai, Ian-Lih,Leou, Shiow-Piaw. "ALKALOIDS OF DEHAASIA TRIANDRA". . p. 615 - 620. Retrieved 2007/10/02.
• 2、 NAKANO. "Studies on the alkaloids of magnoliaceous plants. XIV. Alkaloids of Magnolia grandiflora L. (3). Structure of magnoflorine.". . p. 329 - 334. Retrieved 2007/10/04.