C₂₇H₃₃N₃O₄ClF

Base Information

• Chemical Name: C₂₇H₃₃N₃O₄ClF
• CAS No.: 960207-27-6
• Molecular Formula: C₂₇H₃₃ClFN₃O₄
• Molecular Weight: 518.028
• Mol file: 960207-27-6.mol

Synonyms:

Chemical Property of C₂₇H₃₃N₃O₄ClF

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₇H₃₃N₃O₄ClF

There total 6 articles about C₂₇H₃₃N₃O₄ClF which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C13H17N2OCl*C2HF3O2 + N-Boc-D-2-F-Phe (114873-10-8) → C27H33N3O4ClF (960207-27-6)

Guidance literature:

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2007.09.032

Reference yield:

7-Chlor-1,3,4,5-tetrahydro-2H-benzazepin-2-on (22344-77-0) → C27H33N3O4ClF (960207-27-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 60 °C

2.1: N,N,N,N,-tetramethylethylenediamine; trimethylsilyl iodide; iodine / dichloromethane / -10 - 0 °C

2.2: 40 °C

3.1: hydrogen; palladium on activated charcoal / ethanol / 760.05 Torr

4.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane

With trimethylsilyl iodide; N,N,N,N,-tetramethylethylenediamine; palladium on activated charcoal; hydrogen; iodine; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

DOI:10.1016/j.bmcl.2013.03.121

Reference yield:

C13H16ClNO → C27H33N3O4ClF (960207-27-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: N,N,N,N,-tetramethylethylenediamine; trimethylsilyl iodide; iodine / dichloromethane / -10 - 0 °C

1.2: 40 °C

2.1: hydrogen; palladium on activated charcoal / ethanol / 760.05 Torr

3.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane

With trimethylsilyl iodide; N,N,N,N,-tetramethylethylenediamine; palladium on activated charcoal; hydrogen; iodine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2013.03.121

upstream raw materials:

N-Boc-D-2-F-Phe

C₁₃H₁₇ClN₂O

7-Chlor-1,3,4,5-tetrahydro-2H-benzazepin-2-on

Refernces

• 1、 -. "BENZAZEPINONES AS SODIUM CHANNEL BLOCKERS". Page/Page column 53; 57. . Retrieved 2008/06/13.