N-hydroxy-3-(3-phenoxyphenyl)-2-propenamine hydrochloride

Base Information

• Chemical Name: N-hydroxy-3-(3-phenoxyphenyl)-2-propenamine hydrochloride
• CAS No.: 112270-89-0
• Molecular Formula: C₁₅H₁₃NO₂*ClH
• Molecular Weight: 275.735
• Mol file: 112270-89-0.mol

Synonyms:

Chemical Property of N-hydroxy-3-(3-phenoxyphenyl)-2-propenamine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-hydroxy-3-(3-phenoxyphenyl)-2-propenamine hydrochloride

There total 4 articles about N-hydroxy-3-(3-phenoxyphenyl)-2-propenamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[(E)-3-(3-Phenoxy-phenyl)-allyl]-O-(tetrahydro-pyran-2-yl)-hydroxylamine (112270-88-9) → N-hydroxy-3-(3-phenoxyphenyl)-2-propenamine hydrochloride (112270-89-0)

Guidance literature:

With hydrogenchloride; In methanol;

DOI:10.1021/jm00398a001

Reference yield:

3-Phenoxybenzaldehyde (39515-51-0) → N-hydroxy-3-(3-phenoxyphenyl)-2-propenamine hydrochloride (112270-89-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) pyridine, piperidine

2: 1.) DIBAL, 2.) 48percent HBr / 2.) Et₂O, hexane

3: dimethylformamide

4: HCl(conc.) / methanol

With piperidine; pyridine; hydrogenchloride; hydrogen bromide; diisobutylaluminium hydride; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00398a001

Reference yield:

E-3-(3-phenoxyphenyl)-1-bromoprop-2-ene (112270-87-8) → N-hydroxy-3-(3-phenoxyphenyl)-2-propenamine hydrochloride (112270-89-0)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethylformamide

2: HCl(conc.) / methanol

With hydrogenchloride; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00398a001

upstream raw materials:

N-[(E)-3-(3-Phenoxy-phenyl)-allyl]-O-(tetrahydro-pyran-2-yl)-hydroxylamine

3-Phenoxybenzaldehyde

E-3-(3-phenoxyphenyl)-1-bromoprop-2-ene

methyl 3-<(4-phenoxy)phenyl>propenoate

Downstream raw materials:

N-(3-phenoxycinnamyl)acetohydroxamic acid

N-Acetoxy-N-[(E)-3-(3-phenoxy-phenyl)-allyl]-acetamide

Refernces