phenylthiocarbamyl-Ala-Leu-Ala-Asp-primaquine

Base Information

• Chemical Name: phenylthiocarbamyl-Ala-Leu-Ala-Asp-primaquine
• CAS No.: 158307-00-7
• Molecular Formula: C₃₈H₅₂N₈O₇S
• Molecular Weight: 764.946
• Mol file: 158307-00-7.mol

Synonyms:

Chemical Property of phenylthiocarbamyl-Ala-Leu-Ala-Asp-primaquine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phenylthiocarbamyl-Ala-Leu-Ala-Asp-primaquine

There total 9 articles about phenylthiocarbamyl-Ala-Leu-Ala-Asp-primaquine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Boc-Ala-Leu-Ala-Asp(OBzl)-primaquine (158306-60-6) → phenylthiocarbamyl-Ala-Leu-Ala-Asp-primaquine (158307-00-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 87 percent / H₂ / 10percent Pd/C / methanol / 3 h / Ambient temperature

2: 90 percent / 0.5 h / Ambient temperature

3: pyridine; H₂O / 2 h / 50 °C

With hydrogen; palladium on activated charcoal; In pyridine; methanol; water;

DOI:10.1002/jps.2600840226

Reference yield:

Asp(OBzl)-primaquine → phenylthiocarbamyl-Ala-Leu-Ala-Asp-primaquine (158307-00-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide / 1.) DMF, 0 deg C, 5 min; r.t., 2.) DMF, r.t.

2: 87 percent / H₂ / 10percent Pd/C / methanol / 3 h / Ambient temperature

3: 90 percent / 0.5 h / Ambient temperature

4: pyridine; H₂O / 2 h / 50 °C

With hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In pyridine; methanol; water;

DOI:10.1002/jps.2600840226

Reference yield:

N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) → phenylthiocarbamyl-Ala-Leu-Ala-Asp-primaquine (158307-00-7)

Guidance literature:

Multi-step reaction with 8 steps

1: 1.) N,N'-dicyclohexylcarbodiimide, 2.) N-methylmorpholine / 1.) CH₂Cl₂, 0 deg C, 30 min, 2.) CH₂Cl₂, r.t., 20 h, pH = 7.5 - 9

2: 98 percent / 1M HCl/AcOH / 0.67 h / Ambient temperature

3: 1.) N,N'-dicyclohexylcarbodiimide, 2.) triethylamine / 1.) CH₂Cl₂, 0 deg C, 30 min, 2.) CH₂Cl₂, r.t., 20 h, pH = 7.5 - 9

4: 94 percent / H₂ / 10percent Pd/C / methanol / Ambient temperature

5: 1.) 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide / 1.) DMF, 0 deg C, 5 min; r.t., 2.) DMF, r.t.

6: 87 percent / H₂ / 10percent Pd/C / methanol / 3 h / Ambient temperature

7: 90 percent / 0.5 h / Ambient temperature

8: pyridine; H₂O / 2 h / 50 °C

With 4-methyl-morpholine; hydrogenchloride; hydrogen; benzotriazol-1-ol; acetic acid; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In pyridine; methanol; water;

DOI:10.1002/jps.2600840226

upstream raw materials:

phenyl isothiocyanate

N-tert-butoxycarbonyl-L-leucine

N-((tert-butoxycarbonyl)-L-leucyl)-L-alanine benzyl ester

Boc-Ala-Leu-Ala

Downstream raw materials:

phenylthiocarbamyl-Leu-Ala-Asp-primaquine

(S)-5-methyl-3-phenyl-2-thioxoimidazolidin-4-one

Leu-Ala-Asp-primaquine

Refernces