meptazinol hydrobromide

Base Information

• Chemical Name: meptazinol hydrobromide
• CAS No.: 27180-92-3
• Molecular Formula: BrH*C₁₅H₂₃NO
• Molecular Weight: 314.266
• Mol file: 27180-92-3.mol

Synonyms:

Chemical Property of meptazinol hydrobromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of meptazinol hydrobromide

There total 8 articles about meptazinol hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

caprolactam (105-60-2,9012-16-2) → meptazinol hydrobromide (27180-92-3)

Guidance literature:

Multi-step reaction with 7 steps

1: 1.) sodamide / 1.) toluene, reflux, 30 min, 2.) toluene, reflux, 30 min

2: 1.) butyl lithium, diisopropylamine / 1.) hexane/THF, 0 to -10 deg C, 10 min, 2.) THF, amb. temp., 1.5 h

3: 88 percent / bromine / CH₂Cl₂ / 1 h / 30 °C

4: 90 percent / aq. sodium hydroxide / Ambient temperature

5: 1.) sodium amide / 1.) toluene, reflux, 2 h, 2.) THF, 2 h

6: 84 percent / lithium aluminium hydride / tetrahydrofuran / 2 h / Heating

7: 48 percent hydrobromic acid / 1 h / Heating

With sodium hydroxide; lithium aluminium tetrahydride; n-butyllithium; hydrogen bromide; bromine; sodium amide; diisopropylamine; In tetrahydrofuran; dichloromethane;

Reference yield:

1-methyl-2-azepanone (2556-73-2) → meptazinol hydrobromide (27180-92-3)

Guidance literature:

Multi-step reaction with 6 steps

1: 1.) butyl lithium, diisopropylamine / 1.) hexane/THF, 0 to -10 deg C, 10 min, 2.) THF, amb. temp., 1.5 h

2: 88 percent / bromine / CH₂Cl₂ / 1 h / 30 °C

3: 90 percent / aq. sodium hydroxide / Ambient temperature

4: 1.) sodium amide / 1.) toluene, reflux, 2 h, 2.) THF, 2 h

5: 84 percent / lithium aluminium hydride / tetrahydrofuran / 2 h / Heating

6: 48 percent hydrobromic acid / 1 h / Heating

With sodium hydroxide; lithium aluminium tetrahydride; n-butyllithium; hydrogen bromide; bromine; sodium amide; diisopropylamine; In tetrahydrofuran; dichloromethane;

Reference yield:

2-Chloroanisole (766-51-8) → meptazinol hydrobromide (27180-92-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) butyl lithium, 2,2,6,6-tetramethylpiperidine / 1.) hexane/THF, 0 deg C, 10 min, 2.) 30 min

2: 1.) sodium amide / 1.) toluene, reflux, 2 h, 2.) THF, 2 h

3: 84 percent / lithium aluminium hydride / tetrahydrofuran / 2 h / Heating

4: 48 percent hydrobromic acid / 1 h / Heating

With 2,2,6,6-tetramethyl-piperidine; lithium aluminium tetrahydride; n-butyllithium; hydrogen bromide; sodium amide; In tetrahydrofuran;

upstream raw materials:

3-ethylhexahydro-3-(3-methoxyphenyl)-1-methyl<1H>azepine

caprolactam

1-methyl-2-azepanone

2-Chloroanisole

Refernces