(3R,7R)-3,7,11-Trimethyl-dodecanoic acid [(R)-1-(4-nitro-phenyl)-ethyl]-amide

Base Information

• Chemical Name: (3R,7R)-3,7,11-Trimethyl-dodecanoic acid [(R)-1-(4-nitro-phenyl)-ethyl]-amide
• CAS No.: 56994-97-9
• Molecular Formula: C₂₃H₃₈N₂O₃
• Molecular Weight: 390.566
• Mol file: 56994-97-9.mol

Synonyms:

Chemical Property of (3R,7R)-3,7,11-Trimethyl-dodecanoic acid [(R)-1-(4-nitro-phenyl)-ethyl]-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R,7R)-3,7,11-Trimethyl-dodecanoic acid [(R)-1-(4-nitro-phenyl)-ethyl]-amide

There total 8 articles about (3R,7R)-3,7,11-Trimethyl-dodecanoic acid [(R)-1-(4-nitro-phenyl)-ethyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-Citronellal (2385-77-5) → (3R,7R)-3,7,11-Trimethyl-dodecanoic acid [(R)-1-(4-nitro-phenyl)-ethyl]-amide (56994-97-9)

Guidance literature:

Multi-step reaction with 7 steps

1: NaBH₄

2: 96 percent / H₂ / Pd

3: 82 percent / HBr

4: 1.) Mg 2.) copper(II) acetylacetonate / 1.) THF 2.) THF, room temp., 24 h

5: 95 percent / Rh<(-)-BINAP>2ClO₄ / tetrahydrofuran / 15 h / 100 °C

6: 20percent sulfuric acid / toluene / 1 h / 0 °C

With copper acetylacetonate; sodium tetrahydroborate; sulfuric acid; hydrogen bromide; hydrogen; magnesium; bis[(S)-(-)-binap]rhodium(I) perchlorate; palladium; In tetrahydrofuran; toluene;

DOI:10.1016/S0040-4039(00)98889-0

Reference yield:

(3R)-citronellol (1117-61-9) → (3R,7R)-3,7,11-Trimethyl-dodecanoic acid [(R)-1-(4-nitro-phenyl)-ethyl]-amide (56994-97-9)

Guidance literature:

Multi-step reaction with 6 steps

1: 96 percent / H₂ / Pd

2: 82 percent / HBr

3: 1.) Mg 2.) copper(II) acetylacetonate / 1.) THF 2.) THF, room temp., 24 h

4: 95 percent / Rh<(-)-BINAP>2ClO₄ / tetrahydrofuran / 15 h / 100 °C

5: 20percent sulfuric acid / toluene / 1 h / 0 °C

With copper acetylacetonate; sulfuric acid; hydrogen bromide; hydrogen; magnesium; bis[(S)-(-)-binap]rhodium(I) perchlorate; palladium; In tetrahydrofuran; toluene;

DOI:10.1016/S0040-4039(00)98889-0

Reference yield:

1-(benzenesulfonyl)-2-methyl-4-chloro-2-butene (59277-17-7) → (3R,7R)-3,7,11-Trimethyl-dodecanoic acid [(R)-1-(4-nitro-phenyl)-ethyl]-amide (56994-97-9)

Guidance literature:

Multi-step reaction with 5 steps

2: 1.) Mg 2.) copper(II) acetylacetonate / 1.) THF 2.) THF, room temp., 24 h

3: 95 percent / Rh<(-)-BINAP>2ClO₄ / tetrahydrofuran / 15 h / 100 °C

4: 20percent sulfuric acid / toluene / 1 h / 0 °C

With copper acetylacetonate; sulfuric acid; magnesium; bis[(S)-(-)-binap]rhodium(I) perchlorate; In tetrahydrofuran; toluene;

DOI:10.1016/S0040-4039(00)98889-0

upstream raw materials:

(R)-2-methyl-p-nitrobenzylamine

(3R,7R,5E)-3,7,11-trimethyldodecan-1-al

(R)-Citronellal

(3R)-citronellol

Refernces