Boc-Ile-Ala-Cys(Dppm)-Ala-Cys(Dppm)-Ala-OPic

Base Information

• Chemical Name: Boc-Ile-Ala-Cys(Dppm)-Ala-Cys(Dppm)-Ala-OPic
• CAS No.: 62982-19-8
• Molecular Formula: C₆₈H₇₇N₉O₉S₂
• Molecular Weight: 1228.55
• Mol file: 62982-19-8.mol

Synonyms:

Chemical Property of Boc-Ile-Ala-Cys(Dppm)-Ala-Cys(Dppm)-Ala-OPic

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Boc-Ile-Ala-Cys(Dppm)-Ala-Cys(Dppm)-Ala-OPic

There total 16 articles about Boc-Ile-Ala-Cys(Dppm)-Ala-Cys(Dppm)-Ala-OPic which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diphenyl(pyridin-4-yl)methanol (1620-30-0) → Boc-Ile-Ala-Cys(Dppm)-Ala-Cys(Dppm)-Ala-OPic (62982-19-8)

Guidance literature:

Multi-step reaction with 7 steps

1: 64 percent / boron trifluoride etherate / acetic acid / 48 h / 60 °C

2: 97 percent / dioxane; H₂O / 48 h / 23 °C / pH 9.8

3: 93 percent / dicyclohexylcarbodi-imide, 1-hydroxybenzotriazole / tetrahydrofuran

4: trifluoroacetic acid

5: 90 percent / dicyclohexylcarbodi-imide, 1-hydroxybenzotriazole / dimethylformamide

6: trifluoroacetic acid

7: 80 percent / dicyclohexylcarbodi-imide, 1-hydroxybenzotriazole / dimethylformamide

With boron trifluoride diethyl etherate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; water; acetic acid; N,N-dimethyl-formamide;

DOI:10.1039/P19810000522

Reference yield:

4-Benzoylpyridine (14548-46-0) → Boc-Ile-Ala-Cys(Dppm)-Ala-Cys(Dppm)-Ala-OPic (62982-19-8)

Guidance literature:

Multi-step reaction with 8 steps

1: 88 percent / diethyl ether / 1.) reflux, 2 h, 2.) room temperature, 16 h

2: 64 percent / boron trifluoride etherate / acetic acid / 48 h / 60 °C

3: 97 percent / dioxane; H₂O / 48 h / 23 °C / pH 9.8

4: 93 percent / dicyclohexylcarbodi-imide, 1-hydroxybenzotriazole / tetrahydrofuran

5: trifluoroacetic acid

6: 90 percent / dicyclohexylcarbodi-imide, 1-hydroxybenzotriazole / dimethylformamide

7: trifluoroacetic acid

8: 80 percent / dicyclohexylcarbodi-imide, 1-hydroxybenzotriazole / dimethylformamide

With boron trifluoride diethyl etherate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; diethyl ether; water; acetic acid; N,N-dimethyl-formamide;

DOI:10.1039/P19810000522

Reference yield:

phenylmagnesium bromide → Boc-Ile-Ala-Cys(Dppm)-Ala-Cys(Dppm)-Ala-OPic (62982-19-8)

Guidance literature:

Multi-step reaction with 8 steps

1: 88 percent / diethyl ether / 1.) reflux, 2 h, 2.) room temperature, 16 h

2: 64 percent / boron trifluoride etherate / acetic acid / 48 h / 60 °C

3: 97 percent / dioxane; H₂O / 48 h / 23 °C / pH 9.8

4: 93 percent / dicyclohexylcarbodi-imide, 1-hydroxybenzotriazole / tetrahydrofuran

5: trifluoroacetic acid

6: 90 percent / dicyclohexylcarbodi-imide, 1-hydroxybenzotriazole / dimethylformamide

7: trifluoroacetic acid

8: 80 percent / dicyclohexylcarbodi-imide, 1-hydroxybenzotriazole / dimethylformamide

With boron trifluoride diethyl etherate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; diethyl ether; water; acetic acid; N,N-dimethyl-formamide;

DOI:10.1039/P19810000522

upstream raw materials:

pyridine-4-methanol

diphenyl(pyridin-4-yl)methanol

4-Benzoylpyridine

tert-butyloxycarbonylalanyl-4-pyridylmethylester

Refernces