N-(methoxy(methyl)phosphinyl)-L-phenylalanine benzyl ester

Base Information

• Chemical Name: N-(methoxy(methyl)phosphinyl)-L-phenylalanine benzyl ester
• CAS No.: 84558-50-9
• Molecular Formula: C₁₈H₂₂NO₄P
• Molecular Weight: 347.351
• Mol file: 84558-50-9.mol

Synonyms:

Chemical Property of N-(methoxy(methyl)phosphinyl)-L-phenylalanine benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(methoxy(methyl)phosphinyl)-L-phenylalanine benzyl ester

There total 1 articles about N-(methoxy(methyl)phosphinyl)-L-phenylalanine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl methylphosphonochloridate (1066-52-0) + L-phenylalanine benzyl ester p-tosylate (1738-78-9) → N-(methoxy(methyl)phosphinyl)-L-phenylalanine benzyl ester (84558-50-9,84558-58-7)

Guidance literature:

With triethylamine; In chloroform; at 21 ℃; for 18h;

DOI:10.1021/ja00344a032

Reference yield:

N-(methoxy(methyl)phosphinyl)-L-phenylalanine benzyl ester (84558-50-9,84558-58-7) → N-(hydroxy(methyl)phosphinyl)-L-phenylalanine, disodium salt (84558-45-2)

Guidance literature:

Multi-step reaction with 4 steps

1: PCl₅ / CHCl₃ / 5 h / 21 °C

2: 0.22 g / NH₃ gas / CHCl₃ / 0.2 h / 21 °C

3: 1.) H₂, N-methylmorpholine, 2.) NaOD / 5percent Pd/C / 0.5 h / 21 °C / 2.) D₂O

4: 2.0 N NaOD / D₂O / 21 °C

With 4-methyl-morpholine; deuteriated sodium hydroxide; phosphorus pentachloride; ammonia; hydrogen; palladium on activated charcoal; In chloroform; water-d2;

DOI:10.1021/ja00344a032

Reference yield:

N-(methoxy(methyl)phosphinyl)-L-phenylalanine benzyl ester (84558-50-9,84558-58-7) → N-(methoxy(methyl)phosphinyl)-L-phenylalanine, sodium salt (84621-21-6,84621-22-7)

Guidance literature:

Multi-step reaction with 3 steps

1: PCl₅ / CHCl₃ / 5 h / 21 °C

2: 0.22 g / NH₃ gas / CHCl₃ / 0.2 h / 21 °C

3: H₂, N-methylmorpholine / 5percent Pd/C / 0.5 h / 21 °C

With 4-methyl-morpholine; phosphorus pentachloride; ammonia; hydrogen; palladium on activated charcoal; In chloroform;

DOI:10.1021/ja00344a032

upstream raw materials:

methyl methylphosphonochloridate

L-phenylalanine benzyl ester p-tosylate

Downstream raw materials:

N-(hydroxy(methyl)phosphinyl)-L-phenylalanine amide, sodium salt

N-(methoxy(methyl)phosphinyl)-L-phenylalanine amide

N-(methoxy(methyl)phosphinyl)-L-phenylalanine amide

N-(methoxy(methyl)phosphinyl)-L-phenylalanine amide