2β-acetamido-3a-phenylthio<3-(2)H>-5α-cholestane

Base Information

• Chemical Name: 2β-acetamido-3a-phenylthio<3-(2)H>-5α-cholestane
• CAS No.: 106145-76-0
• Molecular Formula: C₃₅H₅₅NOS
• Molecular Weight: 538.886
• Mol file: 106145-76-0.mol

Synonyms:

Chemical Property of 2β-acetamido-3a-phenylthio<3-(2)H>-5α-cholestane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2β-acetamido-3a-phenylthio<3-(2)H>-5α-cholestane

There total 3 articles about 2β-acetamido-3a-phenylthio<3-(2)H>-5α-cholestane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

<3-(2)H>-5α-cholest-2-ene (72457-83-1) + diphenyldisulfane (882-33-7) + acetonitrile (75-05-8,26809-02-9) → 2β-acetamido-3a-phenylthio<3-(2)H>-5α-cholestane (106145-76-0)

Guidance literature:

With tetrabutylammonium tetrafluoroborate; In dichloromethane; at 40 ℃; for 5h; electrolysis;

Reference yield:

2β-bromo-5α-cholestan-3-one (2042-08-2) → 2β-acetamido-3a-phenylthio<3-(2)H>-5α-cholestane (106145-76-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 84 percent / methan⁽²⁾H-ol, sodium borodeuteride / 1 h / Ambient temperature

2: 56 percent / zinc powder, acetic acid / 0.5 h

3: 33 percent / Bu₄NBF₄ electrolyte / CH₂Cl₂ / 5 h / 40 °C / electrolysis

With sodium borodeuteride; deuteromethanol; tetrabutylammonium tetrafluoroborate; acetic acid; zinc; In dichloromethane;

Reference yield:

2β-bromo<3α-(2)H>-5α-cholestan-3β-ol (106145-85-1) → 2β-acetamido-3a-phenylthio<3-(2)H>-5α-cholestane (106145-76-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 56 percent / zinc powder, acetic acid / 0.5 h

2: 33 percent / Bu₄NBF₄ electrolyte / CH₂Cl₂ / 5 h / 40 °C / electrolysis

With tetrabutylammonium tetrafluoroborate; acetic acid; zinc; In dichloromethane;

upstream raw materials:

<3-(2)H>-5α-cholest-2-ene

diphenyldisulfane

acetonitrile

2β-bromo-5α-cholestan-3-one

Refernces