5-chloro-N-((1-(4-(2-oxopyridin-1(2H)-yl)phenyl)-1H-imidazol-4-yl)methyl)thiophene-2-carboxamide phosphate

Base Information

• Chemical Name: 5-chloro-N-((1-(4-(2-oxopyridin-1(2H)-yl)phenyl)-1H-imidazol-4-yl)methyl)thiophene-2-carboxamide phosphate
• CAS No.: 1313610-84-2
• Molecular Formula: C₂₀H₁₅ClN₄O₂S*H₃O₄P
• Molecular Weight: 508.879
• Mol file: 1313610-84-2.mol

Synonyms:

Chemical Property of 5-chloro-N-((1-(4-(2-oxopyridin-1(2H)-yl)phenyl)-1H-imidazol-4-yl)methyl)thiophene-2-carboxamide phosphate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-chloro-N-((1-(4-(2-oxopyridin-1(2H)-yl)phenyl)-1H-imidazol-4-yl)methyl)thiophene-2-carboxamide phosphate

There total 8 articles about 5-chloro-N-((1-(4-(2-oxopyridin-1(2H)-yl)phenyl)-1H-imidazol-4-yl)methyl)thiophene-2-carboxamide phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-Chloro-N-((1-(4-(2-oxopyridin-1(2H)-yl)phenyl)-1H-imidazol-4-yl)methyl)thiophene-2-carboxamide → 5-chloro-N-((1-(4-(2-oxopyridin-1(2H)-yl)phenyl)-1H-imidazol-4-yl)methyl)thiophene-2-carboxamide phosphate (1313610-84-2)

Guidance literature:

With phosphoric acid; In tetrahydrofuran; isopropyl alcohol; for 16h; Product distribution / selectivity;

Reference yield:

2-hydroxypyridin (142-08-5) → 5-chloro-N-((1-(4-(2-oxopyridin-1(2H)-yl)phenyl)-1H-imidazol-4-yl)methyl)thiophene-2-carboxamide phosphate (1313610-84-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium carbonate; copper(l) iodide / dimethyl sulfoxide / 3 h / 120 °C / Industry scale

2.1: potassium carbonate; L-proline; copper(l) iodide / dimethyl sulfoxide / 3.5 h / 120 °C / Industry scale

3.1: toluene / 0.25 h / Industry scale; Inert atmosphere

3.2: 4 h / 100 °C / Industry scale

3.3: 35 °C / Industry scale

4.1: phosphoric acid / isopropyl alcohol; tetrahydrofuran / 16 h

With copper(l) iodide; phosphoric acid; potassium carbonate; L-proline; In tetrahydrofuran; dimethyl sulfoxide; isopropyl alcohol; toluene;

Reference yield:

5-chlorothiophene-2-carboxamide (22353-82-8) → 5-chloro-N-((1-(4-(2-oxopyridin-1(2H)-yl)phenyl)-1H-imidazol-4-yl)methyl)thiophene-2-carboxamide phosphate (1313610-84-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: toluene / 0.25 h / Industry scale; Inert atmosphere

1.2: 4 h / 100 °C / Industry scale

1.3: 35 °C / Industry scale

2.1: phosphoric acid / isopropyl alcohol; tetrahydrofuran / 16 h

With phosphoric acid; In tetrahydrofuran; isopropyl alcohol; toluene;

upstream raw materials:

para-diiodobenzene

2-hydroxypyridin

5-chlorothiophene-2-carboxamide

1-(4-iodophenyl)pyridin-2(1H)-one

Refernces